Advanced Search

2024 Vol. 6, No. 23

Preplanned Studies
A Prospective Cohort Study of Antimony Exposure and Cognitive Impairment in Older Adults — China, 2017–2021
Yidan Qiu, Saisai Ji, Chen Chen, Jinhui Zhou, Jun Wang, Bing Wu, Yuan Wei, Fangyu Li, Xulin Zheng, Lanjing Xu, Zheng Zhang, Feng Zhao, Guangdi Chen, John S. Ji, Yuebin Lyu, Shilu Tong, Xiaoming Shi
2024, 6(23): 537-541. doi: 10.46234/ccdcw2024.104
Abstract(3684) HTML (80) PDF 541KB(7)
Abstract:
What is already known about this topic?

Antimony (Sb) has been identified as a new neurotoxicant that impacts neurological functions in animal studies. However, its effects on the human population remain unknown.

What is added by this report?

The study reveals that there is an association between exposure to Sb and a higher incidence of cognitive impairment in older adults. The dose-response curve demonstrates that the risk of cognitive impairment consistently increased with higher levels of Sb exposure without a discernible threshold.

What are the implications for public health practice?

Reducing exposure to Sb may have a beneficial effect in delaying or preventing the onset of cognitive impairment. This intervention has the potential to significantly decrease the disease burden associated with cognitive impairment, ultimately contributing to social development.

Potential Adverse Outcome Pathways of Chlorinated Organophosphate Flame Retardants
Meiyu Zhou, Huilin Zhang, Qi Xiao, Kexin Li, Xiaoting Li, Haiyan Chu
2024, 6(23): 542-546. doi: 10.46234/ccdcw2024.105
Abstract(3688) HTML (87) PDF 617KB(4)
Abstract:
What is already known about this topic?

Chlorinated organophosphate flame retardants (Cl-OPFRs) are frequently detected chemicals in the environment and biological samples, yet there is a lack of systematic evaluation regarding the adverse effects and toxicological mechanisms of Cl-OPFRs.

What is added by this report?

This study utilizes the adverse outcome pathway (AOP) framework to assess the health implications and mechanisms of Cl-OPFRs, identifying multi-system toxicity, with a particular emphasis on reproductive issues and the possible toxic mechanisms.

What are the implications for public health practice?

These results enhance knowledge of the health hazards linked to Cl-OPFRs, supporting the creation of focused risk evaluations and suitable regulatory actions.

Vital Surveillances
Relationships Between Meteorological Factors and Mongolian Gerbils and Its Flea Burdens — Xilingol League, Inner Mongolia Autonomous Region, China, 2012–2021
Ke Li, Zhenxu Wang, Xiaohui Wei, Haoqiang Ji, Meng Shang, Nan Chang, Zihao Wang, Chenran Guo, Lei Xu, Ning Zhao, Qiyong Liu
2024, 6(23): 547-552. doi: 10.46234/ccdcw2024.107
Abstract(3380) HTML (94) PDF 8980KB(16)
Abstract:
Introduction

Plague is a significant global infectious disease, its spread is linked to host and flea populations. Meteorological conditions can impact flea populations and host densities, hence influencing plague outbreaks. Investigating the connection between meteorological factors, flea populations, and rodent densities in Inner Mongolia’s natural plague foci can aid in predicting and managing plague outbreaks.

Methods

Monthly data on flea index, rodent density, meteorological factors, and normalized difference vegetation index (NDVI) were collected for the study area. Generalized additive modeling (GAM) was used to analyze the non-linear and lag effects of meteorological factors on flea index and rodent density. Structural equation modeling (SEM) was employed to investigate the relationships among meteorological factors, NDVI, flea index, and rodent density.

Results

GAM analysis revealed that temperature, precipitation, relative humidity, and NDVI had significant linear, non-linear, and time-lagged impacts on the density of Mongolian gerbils and the flea index. SEM analysis indicated that meteorological factors could directly influence the density and flea index of Mongolian gerbils, or indirectly impact NDVI, subsequently influencing gerbil density and the flea index.

Conclusions

Meteorological factors primarily influence gerbil density and flea index indirectly by affecting NDVI and the relationship between flea index and gerbil density. This study offers additional support for the significance of meteorological factors and NDVI in influencing the vector-rodent system, offering valuable insights for predicting and managing plague outbreaks.

Methods and Applications
Establishment and Application of a Radiation Dose Rate Model for Nuclear Medicine Examinees
Yuehua Hu, Xinyu He, Wenjia Zhao, Lixin Ding, Meiying You, Zihan Li, Xinyu Liu, Miaomiao Wang, Siyi Chen, Ziwei Lu, Lei Qu, Kuke Ding, Li Zhang, Qiuxian Fu
2024, 6(23): 553-557. doi: 10.46234/ccdcw2024.108
Abstract(3447) HTML (92) PDF 1136KB(9)
Abstract:
Introduction

Traditional methods for determining radiation dose in nuclear medicine include the Monte Carlo method, the discrete ordinate method, and the point kernel integration method. This study presents a new mathematical model for predicting the radiation dose rate in the vicinity of nuclear medicine patients.

Methods

A new algorithm was created by combining the physical model of “cylinder superposition” of the human body with integral analysis to assess the radiation dose rate in the vicinity of nuclear medicine patients.

Results

The model accurately predicted radiation dose rates within distances of 0.1–3.0 m, with a deviation of less than 11% compared to observed rates. The model demonstrated greater accuracy at shorter distances from the radiation source, with a deviation of only 1.55% from observed values at 0.1 m.

Discussion

The model proposed in this study effectively represents the spatial and temporal distribution of the radiation field around nuclear medicine patients and demonstrates good agreement with actual measurements. This model has the potential to serve as a radiation dose rate alert system in hospital environments.

Outbreak Reports
First Case Report of Cystic Echinococcosis Caused by G7 Genotype Echinococcus intermedius Confirmed by Genetic Sequencing — Southern China, December 2023
De Wu, Jiayi Zhang, Jieling Wang, Yangyang Zhao, Lei Wang, Qiang Mao, Haisen Lin, Gang Yao, Guanting Zhang, Xu Wang, Chuizhao Xue, Ying Wang, Jingdiao Chen
2024, 6(23): 558-562. doi: 10.46234/ccdcw2024.109
Abstract(3918) HTML (110) PDF 222KB(17)
Abstract:
What is already known about this topic?

Echinococcosis exhibits a global distribution. In China, the primary endemic area is the northwest region. In December 2023, we documented a case of echinococcosis in an individual lacking any travel or residential history in endemic regions.

What is added by this report?

This is the first laboratory-confirmed case of hepatic echinococcosis reported in Guangdong Province, associated with the G7 genotype of Echinococcus granulosus (E. granulosus). The most probable mode of transmission is a local infection resulting from E. granulosus introduced from endemic regions.

What are the implications for public health practice?

As the circulation of agricultural products increases, it is essential to enhance the quarantine and management of livestock from epidemic areas to prevent and control the spread of echinococcosis to non-epidemic regions.