The new wave of coronavirus disease 2019 (COVID-19) has been threatening the global efforts on disease containment since late 2020. This study aimed to delineate the approaches for COVID-19 case finding in its early outbreak stage in a district of Shanghai Municipality, China, and to evaluate the impact of timeliness on COVID-19 containment. The records of case investigations in Changning District were retrospectively reviewed up to July 2020. Case-finding approaches for local transmission included outpatient monitoring, exposed people quarantining, and contact tracing. The paths of detection of all domestic COVID-19 cases in Changning District in 2020 were analyzed. Overall, 22 local COVID-19 cases were identified. From the 6,160 outpatient visits to designated fever clinics, 58 suspected cases were identified and 8 were subsequently confirmed. The number of people travelling to/from epidemic locations and quarantining within the district was 1,570. During the 14-day quarantine, 9 reported symptoms and 8 were confirmed. Of the 27 close contacts living in the district, 8 reported symptoms during quarantine, and 6 were confirmed. The median time from symptom onset to COVID-19 diagnosis was 6 and 2 days for outpatient monitoring and active case-finding (P=0.003), thus reducing the risk of local transmission. The effective containment in Shanghai may inform public health policy in other regions where strict lockdown is not applicable.
As a respiratory infectious disease, the spread of COVID-19 is influenced by human mobility, population density, and age structures (1). The Changning District of Shanghai possesses a population of nearly 690,000 and the population density is as high as around 18,000 per square kilometer. Apart from the high population density, it is also the home to the Hongqiao Integrated Transportation Hub, which handles a large volume of civil aviation, high-speed and interurban railways, long-distance passenger transportation, subways, ground buses, and taxis (2). As the forefront for COVID-19 containment in Shanghai, Changning District faces substantial threats.
Many regions in the world have moved into a period where the new wave of COVID-19 has been threatening the efforts on disease containment since late 2020. The demand for containing the virus and protecting the economy is high on the agenda for policymakers. However, there are few studies yet to help us understand what works, what is necessary, what is sufficient, and what is too much. Modelling studies showed that highly effective contact tracing and household quarantine were enough to achieve disease containment (3-4), but these studies need to be validated in real-world contexts.
This study was a secondary data analysis based on the records of COVID-19 case investigations in Changning District, Shanghai, from January 16 up to July 14 2020. Three case-finding approaches were applied simultaneously to rapidly identify COVID-19 cases from the district. The first approach was to strengthen outpatient monitoring. In Changning District, 5 fever clinics in 3 general hospitals, 1 traditional Chinese medicine hospital, and 1 community health center were designated for COVID-19 case finding. The second approach was to quarantine individuals with travel history to Hubei Province (within which Wuhan City is located) over the past 14 days since they were suspected to have possible exposure to COVID-19. The third approach was contact tracing for confirmed COVID-19 cases. The latter two approaches were collectively called active case finding. A 14-day home quarantine was required and recommended for all exposed people and identified close contacts. During quarantine, if an individual reported suspected symptoms, they were promptly transferred to a designated fever clinic for clinical examination. (Figure 1)Figure 1. Flowchart for case finding approaches and case management of coronavirus disease 2019 (COVID-19) in Changning District, Shanghai Municipality. Abbreviation: RT-PCR=reverse-transcription polymerase chain reaction.
Quarantine data were collected from January 25 to February 27, 2020 since no local transmission was reported 2 weeks after the diagnosis of last local case, i.e., February 12, in Changning District. Information for individuals who visited designated fever clinics, suspected COVID-19 cases, and confirmed cases were extracted through medical records at the aforementioned 5 hospitals, from January 16 to February 27, 2020. Field epidemiological reports were obtained from Changning District Center for Disease Control and Prevention to extract epidemiological and laboratory data of confirmed cases and their close contacts. Mann-Whitney U test was applied to identify the difference on time from symptom onset to COVID-19 diagnosis between outpatient monitoring and active case-finding in IBM SPSS 22.0 (IBM Corp., Armonk, NY).
A total of 22 local COVID-19 cases and 19 imported cases were detected in Changning District up to July 14, 2020. Of the 22 local cases, 8 (36.4%) were detected by quarantining the people with Hubei Province travel history, 8 (36.4%) were found by outpatient monitoring at designated fever clinics, and 6 (27.3%) were identified by contact tracing (Figure 2). Of the 11 cases with travel history to Hubei Province, 4 arrived in Shanghai before the implementation of quarantine and were identified by outpatient monitoring. For those with close contacts with confirmed cases, 2 had suspected symptoms before their index cases confirmed with COVID-19, thus were found through other approaches rather than contact tracing.Figure 2. Epidemiological links of coronavirus disease 2019 (COVID-19) in Changning District, Shanghai Municipality.
From onset of symptoms to COVID-19 diagnosis, the median time for cases detected from outpatient monitoring, exposed people quarantining, and contact tracing was 6 days [Interquartile Range(IQR): 4–8], 2.5 days (IQR: 2–3) and 2 days (IQR: 1.5–3), respectively. Compared to outpatient monitoring, active case finding approaches significantly reduced the time from symptom onset to diagnosis (P=0.003).
Local COVID-19 cases detected by outpatient monitoring were interspersed between January 27 and February 9, 2020. The total number of outpatient visits to designated fever clinics was 6,160 from January 16 to February 27, and 58 were identified as suspected cases. As a result, 8 (13.8%) patients were confirmed with COVID-19, including one asymptomatic infection. The median duration from their first outpatient visit to diagnosis was 2.5 days (range, 0–10.0).
A total of 2,591 individuals reported themselves having a travel history to the Hubei Province over the past 14 days. Of them, 1,570 (60.6%) were quarantined in Changning District while the rest were quarantined in other districts of Shanghai. During the 14-day quarantine, 0.6% of them (9/1,570) reported fever, cough, diarrhea, or other symptoms, and 8 were confirmed as COVID-19 cases.
Overall, 6 (22.2%) cases were detected from the 27 close contacts who resided in Changning District, including one confirmed after 2 reverse-transcription polymerase chain reaction tests. During the 14-day quarantine, 6 (22.2%) of them reported fever and 3 were confirmed as COVID-19 cases. Another 2 (7.4%) close contacts reported diarrhea or other respiratory symptoms without fever and were subsequently confirmed as COVID-19 cases. One asymptomatic infection was confirmed in a 1-year-old child, who was the youngest COVID-19 case in Changning District. (Figure 3)Figure 3. Contact tracing for confirmed coronavirus disease 2019 (COVID-19) cases in Changning District, Shanghai Municipality. Note: Date of COVID-19 diagnosis was shown for each index cases. Patient X was detected in another district of Shanghai and thus lacked a COVID-19 diagnosis date. Excluded cases included those who completed 14-day quarantine without any symptoms and those who had suspected symptoms during quarantine but received negative reverse-transcription polymerase chain reaction results twice.