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Between May 17 and June 9, 2023, four cases of suspected mushroom poisoning were treated at the People’s Hospital of Chuxiong Yi Autonomous Prefecture. The patients presented with photosensitive dermatitis 21 to 45 hours after ingesting wild “wood ear” mushrooms. The China CDC partnered with the local hospital to investigate the incidents. A comprehensive examination — involving epidemiological investigations, assessing clinical symptoms, and performing morphological and molecular identifications of the toxic mushrooms — suggested that the poisonings were triggered by the inadvertent consumption of Cordierites frondosus (Kobayasi) Korf (C. frondosus). This is a wild mushroom species that bears a striking resemblance to the traditionally edible Auricularia fungi. For two of the patients, the symptoms intensified upon re-exposure to sunlight a week following the ingestion, while the other two exhibited cutaneous photosensitivity up to 12 days post-poisoning. This underscores the alarmingly prolonged duration and the severity of C. frondosus poisoning. Following these incidents, extensive public education and outreach initiatives were disseminated through official platforms to mitigate risks of C. frondosus ingestion and to aid in distinguishing it from safe-to-eat wood ears. Pleasingly, these measures resulted in no further cases being reported until October in Chuxiong.
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On May 17, 2023, two patients suspected of mushroom poisoning were treated at the People’s Hospital of Chuxiong Yi Autonomous Prefecture. Both patients exhibited definitive symptoms of photosensitive dermatitis, such as redness, swelling, itching, blister formation, and sharp pain in the facial region and the dorsal surface of their hands. These symptoms were amplified upon exposure to sunlight. On June 9, the hospital admitted two more patients, revealing similar symptoms (Figure 1A). All patients had consumed “wood ears” prior to the manifestation of these symptoms, prompting the hypothesis of photosensitive dermatitis induced by mushroom poisoning. In response to these cases, the China CDC and the hospital initiated case-finding and epidemiological investigations. The criteria for the definition of these cases were: patients with a history of “wood ears” consumption and manifested symptoms of photosensitive dermatitis during the period of May to June.
Figure 1.Photographs from the patients and morphological characteristics of Cordierites frondosus. (A) Images of photosensitive dermatitis on the dorsal surfaces of the hands from four patients in Chuxiong, Yunnan Province, captured in May and June 2023. (B) Ascoma; (C) Asci of Cordierites frondosus.
Note: Upon admission to the hospital on May 17 and June 9, all patients presented with mild erythema, edema, and vesicles on the dorsum of their hands. Case 1 showed symptom progression with the formation of ulcers and erosions following re-exposure to sunlight on May 23. These ulcers and erosions persisted in Case 1 and Case 2 as of May 30. By June 20, desquamation and scarring were evident on the dorsal surface of the hands in all patients.Four cases, comprised of three males and one female aged 45 to 57, were identified in Cangling District, Chuxiong Yi Autonomous Prefecture, Yunnan Province. The subjects, all rural dwellers who lived approximately 30 kilometers apart, met the case criteria. Two patients manifested gastrointestinal symptoms three hours after mushroom consumption. Subsequent development of photosensitive dermatitis in all patients occurred 21 to 45 hours after consuming 30–50 g of mushrooms. Laboratory results demonstrated minor myocardial damage, lymphocyte irregularities, and a significant increase in the inflammatory cytokine, interleukin 6 (Table 1). Case severity was correlated with high poisonous mushroom intake and exposure to sunlight. Preventive measures included isolating patients from sunlight while therapeutic approach encompassed administration of dexamethasone, vitamin C, chlorpheniramine maleate, and calcium gluconate for anti-inflammatory, antioxidant, and anti-allergic effects. Sufentanil was supplied via infusion pumps for pain relief.
Patients References Case 1 Case 2 Case 3 Case 4 Sex Female Male Male Male Age (years) 57 57 49 45 Medical history - - - Diabetes Mushrooms ingested (g) 50 30 30 20 Ingestion to gastrointestinal symptoms onset (h) 3 3 - - Ingestion to photosensitive dermatitis onset (h) 39 45 21 21 Ingestion to hospital admission (h) 51 51 36 36 Hospitalization duration (days) 13 11 5 5 Outcome Recovered Recovered Recovered Recovered Alanine aminotransferase (U/L) 7–40 28 28 26 44 Aspartate amino transferase (U/L) 13–35 32 48 104 64 Total bilirubin (μmol/L) 3–22 19.4 16.1 21.9 32.7 Blood urea nitrogen (mmol/L) 3.2–7.1 3.42 4.23 6.18 4.31 Serum creatinine (μmol/L) 58–110 42.1 79.2 58.9 47.8 Creatine kinase (U/L) 30–153 56 474 1284 341 Creatine kinase isoenzyme (U/L) 0–24 50.6 44.3 64.7 114.6 Interleukin 6 (pg/mL) 0–7 50.98 36.85 10.02 23.65 White blood cell count (109/L) 3.5–9.5 10.16 15.94 6.37 13.18 Neutrophil count (109/L) 1.8–6.3 8.93 15.5 5.3 12.77 Lymphocyte count (109/L) 1.1–3.2 0.32 0.39 0.67 0.33 Monocyte count (109/L) 0.1–0.6 0.03 0.04 0.4 0.05 Eosinophil count (109/L) 0.02–0.52 0 0 0 0 Basophil count (109/L) 0–0.06 0.01 0.01 0 0.03 Note: “−” indicates no past medical history. Table 1. Demographic and clinical data for four patients with Cordierites frondosus poisoning.
The epidemiological investigation shed light on the unfolding of the poisoning event. On the morning of May 15, 2023 — a day varying between rainy and cloudy weather — a farmer foraged around 80 g of “wood ear” mushrooms from deciduous trees near his home. These mushrooms were subsequently used in a rice noodle lunch dish at 11:00, that he and his wife consumed. By 14:00, both began to exhibit symptoms indicative of food poisoning, such as nausea, vomiting, and diarrhea. For the rest of that day and the next day, which was cloudy transitioning to sunny weather, the couple consumed standard meals excluding mushrooms and partook in outdoor activities. However, by the early morning hours of May 17, a sunny day, they developed photosensitive dermatitis. The distressing symptoms led them to seek medical intervention at 14:00 that day. Their symptoms improved considerably by May 22, another sunny day, upon which they requested discharge. Nevertheless, they had to be readmitted the following day due to deterioration of their symptoms after exposure to sunlight. The condition of their skin, particularly on the back of their hands, worsened, developing into ulcers and erosions. They underwent topical treatments involving fusidic acid cream, halometasone cream, and silver sulfadiazine cream. Discharged on May 28 and May 31, their health showed noticeable improvement. A follow-up examination on June 20 reported significant recovery, however, the backs of their hands displayed extensive scarring (Figure 1A).
On a rainy morning of June 8, 2023, a farmer collected approximately 50 g of “wood ear” mushrooms from deciduous trees near his dwelling to include in his lunch. His younger brother and wife also partook in the noontime meal, which consisted of pan-fried pork, vegetable soup, and rice. The wife, however, refrained from eating the gathered mushrooms. Moreover, both brothers drank alcohol with their meals. That afternoon, they abstained from outdoor activity, consuming a mushroom-free dinner later. By 9:00 the next day, which transitioned from rain to overcast weather, both siblings started showing signs of photosensitive dermatitis (Figure 1A) while laboring outside and sought medical aid at 21:50 that night. It is noteworthy to mention that the farmer’s wife didn’t exhibit any symptoms indicative of poisoning. Both patients witnessed improvement and were discharged from the hospital on June 14, another rainy day. However, during a subsequent check-up conducted on a sunny day on June 20, it was revealed that while their recovery was significant, they continued to feel a mild needle-like sensation on their faces and the backs of their hands when exposed to sunlight.
The mushroom samples were re-gathered from the exact location where the patients had previously collected their specimens. Initial identification was based on the observation of macroscopic features such as color, size, and shape, in addition to microstructural elements like asci and ascospores. For molecular identification, we sequenced the internal transcribed spacer (ITS) sequences, and conducted a phylogenetic analysis using the maximum parsimony (MP) method (ITS GenBank accession numbers OR884094, OR885350). We confirmed that both samples were C. frondosus specimens (Figure 1B&C). By associating the results of species identification with the patients’ clinical manifestations, it was inferred that both episodes were caused by C. frondosus, resulting in photosensitive dermatitis.
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