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Human immunodeficiency virus (HIV) voluntary counseling and testing (VCT) is the process in which individuals who suspect they may be at risk for HIV infection voluntarily seek HIV testing and related services through consultation with healthcare professionals. In 2004, China implemented the “four-free-one-care” policy, which included the establishment of VCT clinics. These clinics were set up in collaboration with the CDC and medical institutions (1). As of the end of 2020, China has successfully established a network of 11,319 VCT clinics nationwide (2). This extensive infrastructure serves as the cornerstone for providing HIV testing and associated behavioral interventions. It is primarily through these VCT clinics that individuals from high-risk populations are able to access essential HIV testing services. Monitoring the HIV cases reported by these VCT clinics can provide valuable insights into the trends in HIV prevalence among high-risk populations (3).
This study analyzes the trends in HIV testing and identify cases within VCT clinics in China from 2015 to 2022. The objective is to offer valuable insights concerning the spatial and temporal distribution patterns of the HIV positivity rate (HPR) among VCT clinics in China.
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Between 2015 and 2022, VCT clinics in China offered a total of 22,075,386 HIV tests, which led to the identification of 260,353 newly-reported HIV cases. These newly-reported cases accounted for 25.0% (260,353/1,043,165) of the total number of HIV cases reported in China during the same period (Table 1). The number of HIV tests showed a consistent increase from 2,397,271 in 2015 to 3,088,305 in 2018, representing a significant rise of 22.3%. However, there was a decline in 2019, with 2,797,414 tests performed in 2022, equivalent to 90.5% (2,797,414/3,088,305) of the 2018 level. Regarding newly-reported HIV cases, there was an upward trend from 33,423 cases in 2015 to 37,407 cases in 2019. However, this trend reversed in 2020, resulting in a decrease in the number of newly-reported cases. In 2022, there were 22,954 cases, accounting for 61.3% (22,954/37,407) of the 2019 count.
Year HIV tests times HIV cases numbers HPR (%) 2015 2,397,271 33,423 1.39 2016 2,504,262 36,066 1.44 2017 2,619,692 36,177 1.38 2018 3,088,305 36,419 1.18 2019 2,892,538 37,407 1.29 2020 2,809,969 28,498 1.01 2021 2,965,935 29,409 0.99 2022 2,797,414 22,954 0.82 Total 22,075,386 260,353 1.18 Abbreviation: HIV=human immunodeficiency virus; VCT=voluntarycounseling and testing; HPR=HIV positivity rate. Table 1. HIV positivity rate for VCT clinics in China, 2015–2022.
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Overall, the HPR for VCT clinics was 1.18% (260,353/22,075,386) between 2015 and 2022 (Table 1). During this period, there was a significant decline in the HPR (AAPC=−7.5%, 95% CI: −12.6%, −2.2%), dropping from 1.39% in 2015 to 0.82% in 2022, with a reduction of 41.01% (Table 1). The APC of HPR was −3.8% (95% CI: −12.4%, 5.6%) from 2015 to 2019. Following this period, the downward trend accelerated from 2020 to 2022 (APC=−12.2%, 95% CI: −26.2%, −12.2%).
None of the 31 PLADs demonstrated the trend of increase in the HPR between 2015 and 2022, as shown in Table 2. Based on the median HPR value (1.10%) observed in the 31 PLADs in 2015, 16 PLADs were classified as high HPR PLADs (HPR>1.10%), as depicted in Figure 1. The remaining 15 PLADs were categorized as low HPR PLADs (HPR<1.10%), also illustrated in Figure 1. Among the 16 high HPR PLADs, seven PLADs, namely Beijing, Shanghai, Fujian, and others, exhibited a statistically significant downward trend (AAPC<0, PAAPC<0.05), with Beijing showing the most rapid decline in HPR (AAPC=−12.6%, 95% CI: −18.1%, −6.7%). Conversely, nine PLADs including Sichuan, Chongqing, Guangdong, and others, did not display a notable downward trend in HPR (PAAPC>0.05). Of the 15 low HPR PLADs, nine, such as Shanxi, Inner Mongolia, Liaoning, and others, showed a downward trend in HPR (AAPC<0, PAAPC<0.05). Notably, Xizang PLAD experienced the most substantial decline in HPR (AAPC=−25.8%, 95% CI: −38.7%, −10.3%). In contrast, six PLADs including Hebei, Jiangxi, Anhui, and others, showed a decrease in HPR, but the changes were not statistically significant (PAAPC>0.05).
Class PLADs HPR (%) AAPC (%) 95% CI (%) P value 2015 2022 Total 1.39 0.82 −7.5 (−12.6, −2.2) 0.006 High HPR-decline Beijing 6.09 2.63 −12.6 (−18.1, −6.7) <0.001 Xinjiang 2.08 0.72 −11.0 (−15.5, −6.2) 0.002 Hainan 2.04 0.86 −10.5 (−18.6, −1.5) 0.023 Fujian 1.48 0.80 −10.3 (−14.9, −5.5) 0.002 Yunnan 3.34 1.58 −7.8 (−12.3, −3.1) 0.007 Henan 1.56 0.95 −7.6 (−10.0, −5.1) <0.001 Shanghai 2.50 1.50 −7.5 (−12.8, −1.9) 0.009 High HPR-no decline Guizhou 1.23 0.58 −7.8 (−17.4, 2.8) 0.144 Sichuan 2.03 0.93 −7.3 (−19.3, 6.4) 0.227 Jiangsu 1.18 0.83 −6.9 (−15.4, 2.4) 0.142 Chongqing 1.58 1.47 −6.8 (−15.0, 2.2) 0.112 Hunan 1.88 1.03 −6.2 (−12.6, 0.6) 0.065 Jilin 2.17 1.38 −5.9 (−13.9, 2.7) 0.174 Guangxi 2.72 1.78 −4.9 (−12.3, 3.1) 0.221 Guangdong 1.35 1.41 −2.1 (−15.7, 13.9) 0.790 Tianjin 1.28 0.79 −1.0 (−9.4, 8.2) 0.789 Low HPR-decline Xizang 0.93 0.16 −25.8 (−38.7, −10.3) 0.009 Gansu 0.45 0.09 −17.4 (−23.2, −11.2) 0.001 Liaoning 0.95 0.38 −13.4 (−21.7, −4.2) 0.005 Inner Mongolia 0.65 0.26 −13.2 (−17.0, −9.2) <0.001 Shanxi 0.80 0.34 −11.3 (−15.8, −6.5) 0.001 Qinghai 0.70 0.28 −10.1 (−16.1, −3.8) 0.009 Shaanxi 0.76 0.47 −7.7 (−12.5, −2.6) 0.010 Heilongjiang 0.95 0.56 −7.5 (−10.1, −4.7) <0.001 Shandong 0.72 0.48 −4.0 (−7.7, −0.2) 0.042 Low HPR-no decline Hebei 0.43 0.33 −3.8 (−10.8, 3.7) 0.308 Hubei 0.88 0.68 −3.8 (−10.3, 3.2) 0.281 Ningxia 0.21 0.29 −2.8 (−10.9, 6.1) 0.462 Anhui 0.89 0.73 −2.4 (−10.9, 6.8) 0.592 Zhejiang 1.04 0.88 −2.1 (−4.8, 0.7) 0.120 Jiangxi 0.78 0.60 −1.2 (−6.0, 3.8) 0.567 Abbreviation: HIV=human immunodeficiency virus; VCT=voluntarycounseling and testing; PLADs=provincial-level administrative divisions; HPR=HIV positivity rate; AAPC=average annual percentage change. Table 2. HIV positivity rate for VCT clinics and average annual percentage change, broken down by PLADs, 2015–2022.
Figure 1.Trends in the HPR for VCT clinics from 2015 to 2022, broken down by PLADs. (A) High HPR-decline; (B) High HPR-no decline; (C) Low HPR-decline; and (D) Low HPR-no decline.
Abbreviation: HIV=human immunodeficiency virus; HPR=HIV positivity rate; VCT=voluntary counseling and testing; PLADs=provincial-level administrative divisions. -
Between 2015 and 2022, the HPR for 367 study units had no spatial autocorrelation (Z=0.84, P=0.128) only in 2016 (Table 3). There was a decrease in the number of HPR hotspots over these years, declining from 41 in 2015 to 23 in 2022. In general, these HPR hotspots were predominantly concentrated in Yunnan, Sichuan, Guangdong, and Guangxi PLADs. Between 2015 and 2017, the hotspots predominantly appeared in Yunnan, Sichuan, Guangxi, and Guangdong PLADs. From 2018 onward, hotspot numbers decreased in Yunnan and Sichuan PLADs, whereas Xinjiang PLAD noted an increase. Between 2020 and 2022, the hotspots were mainly concentrated in Guangdong and Xinjiang PLADs. However, the distribution of cold spots remained relatively stable, mainly concentrated in the northern China, including Shanxi, Inner Mongolia, Ningxia, Shaanxi, Gansu, and Qinghai PLADs.
Year Moran’s I Z Score P value 2015 0.12 3.46 0.002 2016 0.02 0.84 0.128 2017 0.04 1.72 0.045 2018 0.12 3.86 0.007 2019 0.23 7.22 0.001 2020 0.17 5.30 0.003 2021 0.11 4.49 0.003 2022 0.18 6.20 0.001 Table 3. The global autocorrelation of HIV positivity rate in 367 units, 2015–2022.
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Trends in HIV Positivity Rate for VCT Clinics
Temporal Trends in HPR from 2015 to 2022
Spatial Distribution of HPR
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