Download:
-
Breast cancer is the most common cancer and a leading cause of morbidity and mortality among women worldwide (1). In China, approximately 420,000 new breast cancer cases occur annually, accounting for 16.72% of all new cancer cases. Psychological and lifestyle factors, such as depression and poor sleep, may be more prevalent among breast cancer patients. Depression significantly impacts individuals’ daily lives, affecting approximately 300 million people worldwide (2). In China, the prevalence rates of depression are 5.4% for women and 2.7% for men (3). Sleep is essential for emotional and physical health, and poor sleep habits may increase the risk of cancer and mental disorders (4). Persistent insomnia can exacerbate depressive symptoms; indeed, sleep disorders and depression often co-occur and interact. The roles of depression and sleep duration in breast cancer development have been investigated in numerous studies, but the results have been inconsistent.
This study aimed to examine the associations of depressive symptoms and sleep duration with breast cancer among Chinese women using data from the breast cancer cohort study in Chinese women (BCCS-CW). Our findings indicated that women with depressive symptoms experienced an increased risk of breast cancer, particularly in middle-aged and elderly age groups. These results suggest that breast cancer prevention measures and interventions should consider addressing psychological factors.
The BCCS-CW is a large prospective study conducted by the Chinese Center for Disease Control and Prevention across three provincial disease control centers and nine hospitals. The study collected standardized population-based data from Chinese Han women diagnosed with breast cancer. The study design has been previously reported in detail (5). The Ethics Committee of the Chinese Center for Disease Control and Prevention provided approval for the BCCS-CW study, and all participants gave written informed consent prior to participating in face-to-face interviews.
Between 2018 and 2020, the BCCS-CW enrolled 112,118 women who had previously been recruited for a population-based cohort study in 2008. A total of 63,495 women had standardized information collected for analysis in this study. However, only 63,018 participants were included in the final analysis. A total of 477 participants were excluded due to missing data for essential variables, depression scores, or sleep duration, or because of the presence of extreme values.
During the BCCS-CW, multiple data collection methods were employed, including questionnaires, physical measurements, surgical examinations, breast ultrasound and mammography, as well as laboratory tests. A self-developed questionnaire, validated by experts, was utilized to gather basic information via standardized face-to-face interviews carried out by trained and qualified interviewers. The collected data encompassed demographic characteristics such as age and education level.
Depression was assessed in this study using the Center for Epidemiological Studies-Depression (CES-D) Scale, which is included in the BCCS-CW questionnaire and was originally developed for assessing depressive symptomatology in the general population. The CES-D Scale consists of 20 items that evaluate the feelings and behaviors of participants during the previous week. Each item is scored on a scale from 0 (not at all) to 3 (a lot), with higher CES-D scores indicative of more severe depressive symptoms. The total CES-D score ranges from 0 to 60, and scores over 19 are considered reflective of depression.
In this study, participants self-reported their sleep duration in response to the question: “In the past month, how much sleep did you get per night (in hours and minutes)?” Sleep durations ranging from 1 to 23 hours were considered valid and recorded in hours and minutes. Sleep duration was then categorized as follows: <7 hours, ≥7 hours and <9 hours (reference range), or ≥9 hours. Sleep satisfaction was assessed using a 5-point Likert scale, with questionnaire items scored as 1 for very satisfied, 2 for satisfied, 3 for neutral, 4 for dissatisfied, and 5 for very dissatisfied.
Statistical analyses were conducted using SPSS (version 25.0; IBM Corp., Armonk, NY, USA) and R (version 4.2.0; R Development Core Team, Vienna, Austria) software. Continuous data were reported as means±standard deviations, while categorical data were presented as numbers (percentages). For continuous variables, t-tests and analyses of variance were employed, whereas the chi-squared test was applied to categorical variables. Logistic regression analysis was utilized to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
To identify factors associated with depression and sleep duration, univariate and multivariate logistic regression models were constructed employing the “enter” method, with breast cancer as the dependent variable. Significant factors in the univariate models were incorporated as independent variables in the multivariate model, which was adjusted for age, education, marital status, annual family income, and history of benign breast disease. A stratified analysis was also conducted according to menopausal status.
Trend tests were performed by categorizing sleep duration into three groups: less than 7 hours, between 7 and 9 hours, and 9 or more hours. Two-tailed P-values of less than 0.05 were deemed statistically significant. The GGally R package was employed to create a matrix scatterplot depicting age groups, CES-D scores, and sleep duration.
A total of 63,018 Chinese women were included in the analysis, comprising 700 breast cancer cases. Baseline characteristics of the participants are displayed in Table 1. The average age at enrollment was 50.78±11.01 years. Among the participants, 53.05% had an education level of primary school or less, 68.29% had a monthly per capita household income of less than 3,000 CNY, 43.63% were postmenopausal, and more than 70% reported their families’ economic and social status as average. There was a significant difference in age distribution between the breast cancer and control groups (t=7.35, P<0.001), and the mean CES-D score was higher in the breast cancer group (t=2.24, P=0.019). Additionally, the breast cancer group had a shorter sleep duration (t=−2.41, P=0.016) and a lower rate of sleep satisfaction compared to the control group (14.31% vs. 7.32%).
Variable Overall N (%) Breast cancer N (%) Control N (%) t/χ2 P value Age, mean (SD) 50.78±11.01 53.34±9.22 50.75±11.02 7.35 <0.001 Sleep duration, mean (SD) 7.29±1.90 7.09±2.16 7.29±1.90 –2.41 0.016 CES-D score, median (IQR) 3.00 (7.00) 4.00 (6.00) 3.00 (7.00) 2.24 0.019 Education 8.60 0.014 Primary school and below 33,402 (53.05) 393 (56.30) 33,009 (53.01) Junior/senior high school/technical school 27,175 (43.16) 292 (41.83) 26,883 (43.18) Junior college and above 2,384 (3.79) 13 (1.87) 2,371 (3.81) Marital status 1.38 0.240 Unmarried 6,040 (9.58) 58 (9.29) 5,982 (9.60) Married 56,978 (90.42) 642 (91.71) 56,336 (90.40) Average monthly income, CNY 21.83 <0.001 <1,000 12,842 (20.40) 168 (24.07) 12,674 (20.36) 1,000–2,999 30,147 (47.89) 355 (50.86) 29,792 (47.85) 3,000–4,999 13,994 (22.23) 106 (15.19) 13,888 (22.31) ≥5,000 5,978 (9.49) 69 (9.88) 5,909 (9.49) Menopause 89.64 <0.001 Yes 27,495 (43.63) 368 (52.57) 27,127 (43.53) No 32,453 (51.50) 258 (36.86) 32,195 (51.67) Benign breast disease history 2271.40 <0.001 Yes 933 (1.49) 162 (23.18) 771 (1.24) No 61,847 (98.51) 537 (76.82) 61,310 (98.76) Sleep satisfaction 33.55 <0.001 Very satisfied 13,542 (21.58) 96 (13.73) 13,446 (21.67) Satisfied 27,395 (43.65) 313 (44.78) 27,082 (43.64) Neutral 15,934 (25.39) 190 (27.18) 15,744 (25.37) Dissatisfied 5,502 (8.77) 94 (13.45) 5,408 (6.71) Very dissatisfied 382 (0.61) 6 (0.86) 376 (0.61) Economic status 22.72 <0.001 Very good 2,815 (4.47) 25 (3.58) 2,790 (4.48) Good 8,025 (12.75) 75 (10.74) 7,950 (12.77) Common 48,313 (76.73) 516 (73.93) 47,797 (76.77) Poor 3,333 (5.29) 67 (9.60) 3,266 (6.25) Very poor 475 (0.75) 15 (2.15) 460 (0.74) Social status 5.02 0.025 Very good 4,265 (6.77) 42 (6.02) 4,223 (6.78) Good 9,356 (14.86) 92 (13.18) 9,264 (14.88) Common 47,464 (75.39) 530 (75.93) 46,934 (75.38) Poor 1,659 (2.63) 30 (4.30) 1,629 (2.62) Very poor 217 (0.34) 4 (0.57) 213 (0.34) Abbreviation: IQR=interquartile range; BCCS-CW=the Breast Cancer Cohort Study in Chinese Women; SD=standard deviation; CNY=Chinese Yuan. Table 1. The demographic characteristics of the participants of the BCCS-CW, 2020.
Figure 1 illustrates the distribution of depressive symptoms across various age groups. The average CES-D score and the likelihood of depression were observed to increase with age, particularly among older women. The prevalence of depression in each age group was as follows: 20–30 years, 3.2%; 31–40 years, 3.3%; 41–50 years, 2.8%; 51–60 years, 4.1%; 61–70 years, 5.8%; and >70 years, 6.9%.
Figure 1.The distribution of depressive symptoms among Chinese women of different age groups in the BCCS-CW, 2020.
Abbreviation: CES-D score=center for epidemiological studies-depression scale; BCCS-CW=the Breast Cancer Cohort Study in Chinese Women.Figure 2 displays the relationships among age group, CES-D score, and sleep duration, with linear correlations identified among these variables in both the breast cancer and control groups. For the entire cohort, a positive correlation was found between the CES-D score and age (r=0.130, P<0.001), whereas a negative correlation was observed between the CES-D score and sleep duration (r=–0.077, P<0.001). Additionally, a negative correlation was noted between sleep duration and age (r=–0.068, P<0.001).
Figure 2.The correlation between age group, CES-D score, and sleep duration in the BCCS-CW, 2020.
Note: In the presented figure, red dots correspond to the breast cancer group, while blue dots represent the control group. The histograms positioned diagonally illustrate the distribution of age, CES-D scores, and sleep duration. Meanwhile, the scatterplots positioned above and below the diagonal display the relationships between these variables.
Abbreviation: CES-D score=center for epidemiological studies-depression scale. BCCS-CW=the Breast Cancer Cohort Study in Chinese Women.
The univariate logistic regression analysis revealed that the CES-D score, sleep duration, and sleep satisfaction were significantly associated with breast cancer risk (Table 2). After controlling for age, education level, average monthly income, and social status, participants with short sleep duration possessed an OR for incident breast cancer of 1.265 (95% CI: 1.045, 1.531), while those reporting low sleep satisfaction had an OR of 1.174 (95% CI: 1.071, 1.285).
Variable Univariate analyses Multivariate analyses OR (95% CI) P value OR (95% CI) P value Age 1.021 (1.015, 1.028) <0.001 1.021 (1.013, 1.030) <0.001 CES-D score 1.102 (1.002, 1.023) 0.020 1.005 (0.994, 1.017) 0.359 Sleep satisfaction 1.263 (1.167, 1.367) <0.001 1.174 (1.071, 1.285) 0.001 Average monthly income (CNY) 0.874 (0.800, 0.954) 0.003 0.966 (0.875, 1.067) 0.498 Social status 1.154 (1.108, 1.308) 0.025 0.988 (0.863, 1.132) 0.865 Education Primary school and below Reference 1 Reference 1 Junior/senior high school/technical school 0.912 (0.783, 1.062) 0.238 1.156 (0.966, 1.384) 0.113 Junior college and above 0.461 (0.265, 0.801) 0.006 0.805 (0.450, 1.438) 0.463 Sleep duration 7–9 h Reference 1 Reference 1 <7 h 1.529 (1.281, 1.825) <0.001 1.265 (1.045, 1.531) 0.016 ≥9 h 1.148 (0.909, 1.449) 0.248 1.164 (0.920, 1.472) 0.206 Abbreviation: CES-D score=Center for epidemiological studies depression scale; OR=ddds ratio; CI=confidence interval; CNY=Chinese Yuan. Table 2. Univariate and multivariate logistical regression analyses of correlates of breast cancer.
Stratified analysis by menstrual status demonstrated that low sleep satisfaction (OR=1.162; 95% CI: 1.029, 1.311) served as a risk factor for breast cancer in menopausal women (Table 3). In premenopausal women, both depression (OR=1.507; 95% CI: 1.010, 2.249) and low sleep satisfaction (OR=1.192; 95% CI: 1.024, 1.388) contributed to an elevated risk of breast cancer.
Variable Menopausal Premenopausal OR (95% CI) P value OR (95% CI) P value Age 1.033 (1.018, 1.048) <0.001 0.988 (0.974, 1.002) 0.092 Depression 0.145 (0.020, 1.036) 0.054 1.507 (1.010, 2.249) 0.045 Sleep satisfaction 1.192 (1.024, 1.388) 0.024 1.162 (1.029, 1.311) 0.015 Average monthly income (CNY) 1.088 (0.925, 1.281) 0.310 0.834 (0.724, 0.961) 0.012 Social status 1.033 (0.832, 1.283) 0.767 1.014 (0.832, 1.236) 0.891 Education Primary school and below Reference 1.000 reference 1.000 Junior/senior high school/technical school 1.132 (0.848, 1.510) 0.399 1.192 (0.935, 1.520) 0.157 Junior college and above 0.757 (0.368, 1.556) 0.488 1.795 (0.556, 5.791) 0.328 Sleep duration 7–9 h Reference 1.000 reference 1.000 <7 h 1.322 (0.956, 1.828) 0.091 1.237 (0.956, 1.600) 0.106 ≥9 h 1.135 (0.763, 1.688) 0.531 1.230 (0.896, 1.689) 0.201 Abbreviation: OR=Odds ratio; CI=Confidence interval; CNY=Chinese Yuan. Table 3. Multivariate logistical regression analyses in the subgroups divided by menstrual status.
-
In this study, we examined population-based data from a large, ongoing prospective study involving Chinese Han women diagnosed with breast cancer. Our objective was to investigate whether depression and brief sleep duration serve as risk factors contributing to the onset of breast cancer. The findings suggest that depressive symptoms, limited sleep duration, and reduced sleep satisfaction could all be considered risk factors for the development of breast cancer. Consequently, it is crucial that preventive measures and interventions focus on addressing these psychological factors, given their potential impact on the progression of cancer.
Depression, a prevalent mental disorder, is characterized by its primary symptoms of low mood and anhedonia, which can significantly impede an individual's ability to lead a normal life. In this study, 4.4% of the female participants were found to be suffering from depression, with the CES-D scores displaying an increase with age. Notably, the highest prevalence of depression (6.9%) was observed among participants who were 70 years or older, aligning with findings from earlier studies (2).
Prior to accounting for potential confounders, our findings revealed an association between breast cancer incidence and depression, consistent with earlier prospective studies (6). Although multivariable logistic regression results did not corroborate this association across the entire cohort, it remained evident among the premenopausal population. Nevertheless, the overall epidemiological evidence supporting an association between depression and breast cancer remains inconclusive (7–8). Discrepancies among study findings may be attributed to variations in lifestyle and cultural factors across countries, as well as the inclusion of age groups with differing breast cancer incidence rates. To validate these findings, additional large-scale prospective cohort studies are warranted.
Insufficient sleep has been found to negatively impact individuals' health and increase the risk of cancer. Furthermore, poor sleep quality may contribute to compromised immune function and heightened risk of metabolic disorders, potentially leading to obesity and implications for melatonin release. However, the precise mechanisms underpinning these relationships remain elusive. In our study, we observed a link between low sleep satisfaction and increased risk of breast cancer among Chinese women. Specifically, we found that short sleep duration (OR=1.265, P=0.016) constituted a risk factor for breast cancer, while long sleep duration (OR=1.164, P=0.206) did not. Nevertheless, our subgroup analyses did not yield significant associations between sleep duration and breast cancer risk.
Notably, prior research investigating the connection between sleep and breast cancer has produced inconsistent findings (9). Several prospective studies and meta-analyses (10) have not substantiated the association between sleep duration and breast cancer risk. Potential explanations for these discrepancies include variations in criteria for categorizing sleep duration across studies as well as potential biases arising from participants’ self-reported data.
The present study has several limitations that warrant acknowledgment. Firstly, the data were derived from the BCCS-CW study, in which depressive symptoms and sleep characteristics were assessed only once. Consequently, the analysis was restricted to examining the associations between depression, sleep duration, and sleep satisfaction with breast cancer within the Chinese female population. Furthermore, it is only possible to hypothesize if these variables have a causal connection to breast cancer incidence. Lastly, potential information bias might exist due to the reliance on self-reported subjective feelings of participants for certain variables.
The results of this research suggest that public policy should prioritize early psychological interventions and health education as preventative measures for breast cancer, particularly in premenopausal women. Additionally, it is essential to conduct large-scale, prospective cohort studies with follow-up assessments to determine the causal relationships and identify the most effective time for intervention.
-
The Breast Cancer Cohort Study in Chinese Women (BCCS-CW) team.
-
No conflicts of interest.
HTML
| Citation: |
|