In this study, we quantitatively estimated how human contact patterns by age changed in four Chinese cities during the first year of the COVID-19 pandemic. We found that, although the number of contacts increased in the post-epidemic period (approximately six months after the end of the first COVID-19 wave), the average number of contacts per day remained far from the baseline (pre-COVID) level. In addition to the marked reduction in the mean number of contacts per day, the age of the contacted individuals had markedly changed, highlighting a drop in social interactions with work colleagues and in the community. However, we estimated that the increase in mixing patterns was not sufficient to sustain local transmission in Shanghai, while the risk of an epidemic recurrence in the other three cities remained moderate as of November 2020. During the period of our post-epidemic survey (September 16 to November 8, 2020), fewer than 100 local cases were reported in Chinese mainland, and no local cases were reported in the four study locations, which is consistent with our estimates of the potential reproduction number. Finally, we performed a modeling analysis to evaluate the impact of social distancing in the event of a new SARS-CoV-2 outbreak of Omicron BA.5 or another highly transmissible variant. Our findings support that, although vaccination campaigns conducted in China with current vaccine products (as of 2022) are key to mitigating COVID-19 burden, if policymakers aim to prevent SARS-CoV-2 transmission altogether, social distancing measures are still essential.
Although workplaces, schools, and other public places gradually reopened from February to November 2020, many restrictions were still in place to prevent the resurgence of COVID-19. For example, 1) masks were mandated and body temperature was measured to enter indoor public places (9-10); 2) indoor mass gatherings were limited in schools (11); and 3) cinemas and theaters were operating at 75% or lower capacity, with the audience required to wear face masks and maintain a distance of at least one meter (12). From April to August 2020, China experienced several small-scale local outbreaks (13). The interventions adopted as well as the fear of infection may explain the slow resumption of contacts highlighted by our surveys in 2020.
Our results are comparable to those obtained in other studies that have assessed changes in contact patterns linked to the relaxation of COVID-19 control measures (2,14-17). After lifting stay-at-home orders and reopening workplaces in China, the United States, and several European countries, the mean number of contacts varied from two to nine per day, which is consistently higher than the number of contacts during lockdowns but significantly lower than the pre-pandemic level. Moreover, similar to Jarvis et al. (14), we found a larger proportion of indoor contacts than what was observed in the pre-COVID era.
Our study suffers from the traditional limitations of self-reported contact surveys, including recall, self-reporting, and selection biases, which may have affected our results. Although we explained the anonymity and confidentiality of the survey to study participants, we cannot rule out that the number of contacts may have been underreported during the post-epidemic period, when social distancing and other precautions were still in place. Our modeling analysis is intended to provide only general insights and is based on a set of approximations. For instance, the model does not explicitly consider symptomatic and asymptomatic individuals, pre-symptomatic transmission, the effect of individual-level interventions (e.g., test-trace-isolate, mask wearing), or the level of immunity provided by the primary vaccination cycle. Instead, we combine the effects of all these aspects into a single indicator: the effective reproduction number. Although this allowed us to provide a first-level approximation of the reduction of social contacts, more refined analyses are needed to identify the proper interventions required to contain a novel SARS-CoV-2 outbreak and/or mitigate the COVID-19 burden and pressure on the healthcare system.
Our study quantified contact patterns at different time points during the first year of the COVID-19 pandemic in Chinese mainland and provided evidence of a gradual recovery of contact patterns while social distancing measures were gradually relaxed. Moving forward, monitoring mixing patterns could inform authorities about the risk of resurgence of novel outbreaks caused by highly transmissible SARS-CoV-2 variants, and, in the event of an outbreak, social distancing is likely to play a key role in limiting SARS-CoV-2 transmission and mitigating the burden of COVID-19.