Advanced Search

Notes from the Field: The First Outbreak of Omicron Subvariant BA.5.2 — Beijing Municipality, China, July 4, 2022

View author affiliations

Citation:

通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Turn off MathJax
Article Contents

Article Metrics

Article views(6647) PDF downloads(38) Cited by()

Share

Related

The First Outbreak of Omicron Subvariant BA.5.2 — Beijing Municipality, China, July 4, 2022

View author affiliations
  • 1. Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, China
  • 2. Office of Beijing Center for Global Health, Beijing Center for Disease Prevention and Control, Beijing, China
  • 3. Yanqing District Center for Disease Prevention and Control, Beijing, China
  • Corresponding author:

    Da Huo, huoda@bjcdc.org

  • Funding: National Key Research and Development Program of China (2021ZD0114103)
  • Online Date: July 25 2022
    Issue Date: July 29 2022
    doi: 10.46234/ccdcw2022.136
  • On July 4, 2022, the first case of Omicron subvariant BA.5.2 in Beijing Municipality was discovered in Yanqing District. The case was a 49-year-old Chinese male who had arrived in Shanghai Municipality via international flight DL9927 from North Carolina, U.S. on June 15. He stayed in a hotel for the 14-day arrival quarantine and was discharged on June 30. He arrived in Beijing via domestic flight MU5103 on July 1 and was transferred point-to-point from the airport to his residence community in Yanqing District. On July 3, his sample was collected through community mass screening and reported positive in the next morning. The case had received 3 doses of Moderna’s mRNA vaccines in the U.S., with the last shot on May 26, 2022.

    The index case caused an outbreak with a total of 16 cases located in 5 districts within 7 days. Among all cases, 12 were males and 4 were females; 12 received a booster shot, whereas 4 were non-vaccinated.

    The respiratory samples from 16 cases were sequenced by the Next Generating Sequencing (NGS). A total of 13 full genomes were obtained and all belonged to the same lineage BA.5.2, Variant of Concern (VOC)/Omicron. In particular, 11 genomes shared a nucleotide similarity of 100%, 1 genome carried an additional mutation of T29678C, and 1 carried an additional heterozygous mutation of A6821G with a frequency of 59.39%. Phylogenetic analysis indicated the virus was similar to strains in North America, Europe, and Asia in mid-June, which was different from local clusters in Beijing in the same period (Figure 1).

    Figure 1. 

    Neighbor-joining phylogenetic tree of strains in the outbreak.

    Note: The genomes from cases in the outbreak were indicated by red dots. The major VOC/Omicron PANGOLIN lineages were marked and colored on the right. The tree was rooted using strain Wuhan-1 (EPI_ISL_402125).

    Abbreviation: VOC=variant of concern.

    Omicron subvariant BA.5 had surged dramatically to become dominant in the U.S. (1). Research indicated that the Omicron BA.5 subvariant had a growth advantage against other subvariants with a higher ability of immune escape than the BA.1, BA.2, and BA.2.12.1 subvariants (2-5). Continuous surveillance and assessment need to be implemented to respond Omicron subvariant BA.5 in China.

Reference (5)

Citation:

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return