Trends of Mortality in End-Stage Liver Disease — China, 2008–2020

Trends of Mortality in End-Stage Liver Disease in China, 2008–2020 A new study reveals concerning trends in mortality rates for end-stage liver disease in China. The research, conducted between 2008 and 2020, highlights the large number of deaths from this life-threatening condition. The study's findings shed light on the urgent need for improved prevention and treatment strategies to combat the rising mortality rates associated with liver disease. These findings call for increased awareness and action from healthcare providers, policymakers, and the public to address this pressing issue. Journalists interested in reporting on the state of liver disease in China and its implications for public health are encouraged to explore this research.

For more information: https://weekly.chinacdc.cn/en/article/doi/10.46234/ccdcw2023.128

Changes in HIV-1 Subtypes/Sub-Subtypes, and Transmitted Drug Resistance Among ART-Naïve HIV-Infected Individuals — China, 2004–2022

A new study conducted in China reveals significant alterations in the prevalence of different strains of HIV and drug resistance in treatment-naïve individuals between 2004 and 2022. The study, which analyzed sequences from the HIV-1 pol gene region, found a decline in the prevalence of certain strains and an increase in others over time. Additionally, the study highlights an increase in transmitted drug resistance (TDR) to certain drugs, particularly non-nucleoside reverse transcriptase inhibitors (NNRTIs). The overall prevalence of TDR in China was found to be at a moderate level, with NNRTI resistance standing prominently. This poses a challenge to the effectiveness of antiretroviral therapy (ART) regimens, especially among newly diagnosed individuals. Considering China's population of over 1.1 million individuals living with HIV/AIDS, urgent measures to curb TDR are necessary. This study sheds light on the need for increased baseline testing for drug resistance and better management of TDR in low- and middle-income countries.

For more information: https://weekly.chinacdc.cn/en/article/doi/10.46234/ccdcw2023.129