According to the influenza surveillance data from the Chinese National Influenza Center (15), influenza activity continued to increase in February 2023 after the sudden relaxation of COVID-19 control measures; consequently, among the eight study years, the highest influenza activity was observed in 2023, followed by 2020, and the lowest activity was observed in 2021, with no apparent seasonality. In contrast to that in northern China, the influenza activity in southern China was more serious in the summer of 2022. In this period, the ILI+ and influenza-like illness (ILI) in southern China were 23.90 per 1,000 and 75.41 per 1,000 persons, respectively, which were higher than those in northern regions (4.44 per 1,000 and 27.77 per 1,000 persons, respectively). The ILI had a rebound increase in December 2022 and peaked at 130.96 per 1,000 and 86.25 per 1,000 persons in the southern and northern regions, respectively, during the Omicron variant outbreak in China, and resulted in notably increasing ILI cases compared with any other period. In February 2023, ILI+ had the highest values of 54.39 per 1,000 and 51.41 per 1,000 persons in the northern and southern regions, respectively.
To validate the epidemic models used in this study, we performed model calibration for influenza outbreaks in North and South China over five influenza seasons (2015–2016, 2016–2017, 2017–2018, 2018–2019, and 2022–2023). Informed by ILI+ (Figure 1), we used the EAKF algorithm (Methods) to infer the transmission rates in previous influenza seasons and replayed the historical infection pattern in the northern and southern regions of China (Figures 2–3).
We projected the influenza activity between October 9, 2022, and October 1, 2023 (Figure 4), with the transmission rate as the fitted value in the 2015–2019 seasons (Figure 3). During the study period, we estimated that the attack rates were 18.51% (95% CI: 0.00%, 37.78%) and 28.30% (95% CI: 14.77%, 41.82%) in northern and southern China, respectively. The influenza incidence was estimated to peak on March 12, 2023, and March 19, 2023, in northern and southern China, with ILI+ values of 61.28 (95% CI: 0, 160.87) and 66.04 (95% CI: 0, 161.09), respectively, and the outbreaks were predicted to end on June 18 and July 23, 2023, in northern and southern China, respectively. For the influenza season of 2022–2023, the attack rate was estimated to exceed 5% in northern and southern China for 72% and 83% of the epidemics, respectively.
The effective reproduction number Re between October 9, 2022, and October 1, 2023, started at 1.08 (95% CI: 0.51, 1.65) and 1.10 (95% CI: 0.55, 1.67) and reached as high as 2.13 (95% CI: 1.56, 2.70) on February 26, 2023, and 2.44 (95% CI: 1.86, 3.01) on February 26, 2023, while the mean estimates were 0.93 (95% CI: 0.35, 1.51) and 0.96 (95% CI: 0.44, 1.49), respectively, in northern and southern China. In contrast, the mean estimate was 0.97 (95% CI: 0.96, 0.98) and 0.99 (95% CI: 0.98, 1.00), with peak values of 1.60 (95% CI: 1.56, 1.65) and 1.42 (95% CI: 1.41, 1.43), for the period from October 2015 to September 2019 in northern and southern China, respectively.
The estimated proportions of the initially susceptible population (S0) on October 9, 2022, were 0.73 and 0.76 in northern and southern China, respectively. Following the same Re, a higher S0 would cause both a higher ILI+ and attack rate. We further investigated the impact of susceptibility on the attack rate by varying S0 from 50% to 80% across the transmission scenarios (Supplementary Figures S1–S2). In southern China, we estimated that the attack rates were 0.11% (95% CI: 0.04%, 0.19%), 0.45% (95% CI: 0%, 1.12%), 14.00% (95% CI: 3.37%, 24.62%), and 35.72% (95% CI: 18.21%, 53.24%) for S0= 0.5, 0.6, 0.7, and 0.8, respectively. In northern China, we estimated that the attack rates were 0.18% (95% CI: 0.05%, 0.32%), 0.61% (95% CI: 0.00%, 1.26%), 10.27% (95% CI: 0.00%, 24.55%), and 42.54% (95% CI: 18.79%, 66.28%) for S0= 0.5, 0.6, 0.7, and 0.8, respectively.