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Foreword: Facing the Challenge of Tuberculosis: Towards “End TB in China by 2035”

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  • Prof. Yanlin Zhao
    Director, National TB Control and Prevention Center, China CDC.
    Chairman of Research Committee, Chinese Anti-TB Association
    Prof. Jianjun Liu
    Vice Director, China CDC.
    President, Chinese Anti-TB Association
  • [1] Uplekar M, Weil D, Lonnroth K, Jaramillo E, Lienhardt C, Dias HM, et al. WHO’s new end TB strategy. Lancet 2015;385(9979):1799 − 801. http://dx.doi.org/10.1016/S0140-6736(15)60570-0CrossRef
    [2] WHO. Global tuberculosis report 2020. Geneva: World Health Organization; 2020. https://www.who.int/publications/i/item/9789240013131.https://www.who.int/publications/i/item/9789240013131
    [3] Castor K, Mota FB, da Silva RM, Cabral BP, Maciel EL, de Almeida IN, et al. Mapping the tuberculosis scientific landscape among BRICS countries: a bibliometric and network analysis. Mem Inst Oswaldo Cruz 2020;115:e190342. http://dx.doi.org/10.1590/0074-02760190342CrossRef
    [4] Wang LX, Zhang H, Ruan YZ, Chin DP, Xia YY, Cheng SM, et al. Tuberculosis prevalence in China, 1990-2010; a longitudinal analysis of national survey data. Lancet 2014;383(9934):2057 − 64. http://dx.doi.org/10.1016/S0140-6736(13)62639-2).CrossRef
    [5] Ou XC, Li Q, Su D, Xia H, Wang SF, Zhao B, et al. A pilot study: VereMTB detection kit for rapid detection of multidrug-resistant Mycobcterium tuberculosis in clinical sputum samples. PLoS One 2020;15(3):e0228312. http://dx.doi.org/10.1371/journal.pone.0228312CrossRef
    [6] Zhou Y, Anthony R, Wang SF, Ou XC, Liu DX, Zhao YL, et al. The epidemic of multidrug resistant tuberculosis in China in historical and phylogenetic perspectives. J Infect 2020;80(4):444 − 53. http://dx.doi.org/10.1016/j.jinf.2019.11.022CrossRef
    [7] Wang SF, Zhou Y, Zhao B, Ou XC, Xia H, Zheng Y, et al. Characteristics of compensatory mutations in the rpoC gene and their association with compensated transmission of Mycobacterium tuberculosis. Front Med 2020;14(1):51 − 9. http://dx.doi.org/10.1007/s11684-019-0720-xCrossRef
    [8] Xia H, van den Hof S, Cobelens F, Zhou Y, Zhao B, Wang SF, et al. Value of pyrazinamide for composition of new treatment regimens for multidrug-resistant Mycobacterium tuberculosis in China. BMC Infect Dis 2020;20(1):19. http://dx.doi.org/10.1186/s12879-020-4758-9CrossRef
    [9] Meehan CJ, Goig GA, Kohl TA, Verboven L, Dippenaar A, Ezewudo M, et al. Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues. Nat Rev Microbiol 2019;17(9):533 − 45. http://dx.doi.org/10.1038/s41579-019-0214-5CrossRef
    [10] Hicks ND, Carey AF, Yang J, Zhao YL, Fortune SM. Bacterial genome-wide association identifies novel factors that contribute to ethionamide and prothionamide susceptibility in Mycobacterium tuberculosis. mBio 2019;10(2):e00616 − 19. http://dx.doi.org/10.1128/mBio.00616-19CrossRef
    [11] Yang Y, Walker TM, Walker AS, Wilson DJ, Peto TEA, Crook DW, et al. DeepAMR for predicting co-occurrent resistance of Mycobacterium tuberculosis. Bioinformatics 2019;35(18):3240 − 9. http://dx.doi.org/10.1093/bioinformatics/btz067CrossRef
    [12] Liu DX, He WC, Jiang MX, Zhao B, Ou XC, Liu CF, et al. Development of a loop-mediated isothermal amplification coupled lateral flow dipstick targeting erm(41) for detection of Mycobacterium abscessus and Mycobacterium massiliense. AMB Express 2019;9:11. http://dx.doi.org/10.1186/s13568-019-0734-4CrossRef
    [13] Liu LG, Jiang FT, Chen LH, Zhao B, Dong J, Sun LL, et al. The impact of combined gene mutations in inhA and ahpC genes on high levels of isoniazid resistance amongst katG non-315 in multidrug-resistant tuberculosis isolates from China. Emerg Microbes Infect 2018;7(1):1 − 10. http://dx.doi.org/10.1038/s41426-018-0184-0CrossRef
    [14] CRyPTIC Consortium and the 100, 000 Genomes Project, Allix-Béguec C, Arandjelovic I, Bi LJ, Beckert P, Bonnet M, et al. Prediction of susceptibility to first-line tuberculosis drugs by DNA sequencing. N Engl J Med 2018;379(15):1403 − 15. http://dx.doi.org/10.1056/NEJMoa1800474CrossRef
    [15] Hicks ND, Yang J, Zhang XB, Zhao B, Grad YH, Liu LG, et al. Clinically prevalent mutations in Mycobacterium tuberculosis alter propionate metabolism and mediate multidrug tolerance. Nat Microbiol 2018;3(9):1032 − 42. http://dx.doi.org/10.1038/s41564-018-0218-3CrossRef
  • FIGURE 1.  Tuberculosis control and prevention strategy in China.

    FIGURE 2.  Tuberculosis control and prevention key measures.

    FIGURE 3.  Roadmap towards ending tuberculosis epidemic in China.

    Abbreviations: ACF=active case finding; TPT=latent TB=preventive treatment; EPTB=extra pulmonary tuberculosis

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Facing the Challenge of Tuberculosis: Towards “End TB in China by 2035”

  • “The Clock is Ticking” is the theme of 2021 World Tuberculosis (TB) Day. Each year, we recognize on March 24 the important date in 1882 when the German scientist Dr. Robert Koch announced his discovery of the causes of tuberculosis, that is Mycobacterium tuberculosis, which has caused billions of the death in the past. The fight against TB, one of the threats to global public health, needs to be people-oriented, follow sustainable development principles, and encourage knowledge sharing and policy exchange in the world that was endorsed by the World Health Organization’s (WHO) End-TB Strategy (12). In addition, the United Nation (UN) leader’s summit call for further emphasis on TB control and prevention urged the global community to provide treatment to all those with TB in developing countries, to reduce the threat to global public health, and to reduce the economical and labor losses caused by TB (3). World TB Day raises awareness of the challenges that hinder our progress toward the elimination of this devastating disease.

    TB is a global disease. In China, TB has been put into category II notifiable disease since 1996. A systematic TB control and prevention program had been launched in the 1990s and has been supported by national effort and prioritization. As a result, TB prevalence in China was halved between 1990 and 2010, mortality rates fell by almost 80%, and incidence rates fell 3.4% per year (4). Despite these achievements, China continues to have one of the highest TB burdens in the world, ranking number 3 in the world in several TB burden indicators.

  • The Chinese government has been paying close attention to TB control and prevention as the State Council has issued a series of “5-year national TB control programs” (11th, 12th, and 13th) to strengthen the TB control and prevention nationwide and to increase funding for scientific research in terms of diagnostics, digital health, new drugs, new vaccines, and implemental and operational research (57). Chinese scientists and specialists continue to carry on investigative studies to understand the burden of TB, the characteristics of the predominant strains (810), the effectiveness of infection control measures, means of assisting vulnerable populations, novel drug therapies, and technology to support community case management using mobile phones and medical monitors. The scientific community continues to recognize that TB is impeding the further progress and fulfillment of Healthy China 2030.

    Recently, China has established a series of policies and several major measures in its healthcare system, actively and effectively slowed the TB epidemic, and reduced the number of new TB cases by over 300,000 when compared to projections. These are major achievements in TB control and prevention that have had high socioeconomic effectiveness. The central government provided financial support of approximately 1.2 billion CNY for TB control and prevention every year, and local governments and health insurances supplement this figure.

  • The National TB Program (NTP) is committed to strengthening research on strategies and measures for TB control and prevention; organizing and implementing action plans; conducting scientific research on applying these techniques; providing technical guidance, staff training and quality control for disease control and prevention and public health services throughout the country; and acting as the national technical leading work group for TB prevention and control (Figure 1).

    Figure 1.  Tuberculosis control and prevention strategy in China.

    To address these challenges, scientific research and innovation are key to controlling and ultimately eliminating this disease. Innovations in TB control efforts have embraced new tools and approaches to prevent, diagnose, and treat TB and drug-resistant TB (1115). However, the research is continuous and treating TB depends on multidisciplinary and multisectoral collaboration across the country because the problems are complex and multifaceted and cannot be solved simply. Therefore, international and domestic scientists and stakeholders must collaborate in research and development of new vaccines and new anti-TB drugs.

  • TB is a major priority due to the costs and challenges it brings to the basic public health service system, hierarchical medical system, family doctor signing system, and payment of medical costs by categorizing cases (based on diagnosis-related groups, DRGs). These challenges must be overcome by improving service at the county and township levels by further reforming the healthcare system in conjunction with improving basic health insurance, medical care, medical aid, etc.

    China has the capability to act urgently and quickly by partnering with international collaborators. China will, together with international collaborators, harness individual and collective resources under the stewardship by UN and WHO to overcome barriers that impede treatment and address this global challenge (Figure 2).

    Figure 2.  Tuberculosis control and prevention key measures.

  • Based on the ambitious targets of the End TB strategy and the baseline TB incidence rate in 2015 (65/100,000 population), the phased indicator of TB incidence rate in China in 2025, 2030, and 2035 was 33/100,000, 13/100,000, and 7/100,000, respectively. The End TB targets are deliberately ambitious, and any single intervention is unlikely to achieve these goals. Policymakers must identify what interventions and at what level of scale up will be needed to meet the End TB targets at the country level. The main interventions including optimizing the use of existing tools enabled by investments in universal health coverage to scale up the active case-finding targets and improve TB preventive treatment among high-risk population to adopt and scale up novel tools (diagnostics, drugs, and vaccines) (Figure 3).

    Figure 3.  Roadmap towards ending tuberculosis epidemic in China.

    Abbreviations: ACF=active case finding; TPT=latent TB=preventive treatment; EPTB=extra pulmonary tuberculosis

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Citation:

 

Prof. Yanlin Zhao
Director, National TB Control and Prevention Center, China CDC.
Chairman of Research Committee, Chinese Anti-TB Association

 

Prof. Jianjun Liu
Vice Director, China CDC.
President, Chinese Anti-TB Association

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