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In 2018, more than 308 million adults were current smokers in China (1). Quitting smoking has been associated with reduced risks of tobacco-related diseases, premature death, and improved quality of life (2). However, due to its nature as a chronic disease, tobacco dependence is often considered difficult to overcome solely through personal willpower (3). Substantial evidence suggests that interventions from healthcare providers can significantly increase the chances of abstinence from smoking (4). In 2018, a data management platform for smoking cessation clinics (SCCs) was developed. This study examined data from 448 SCCs obtained from the platform between 2019 and 2021 to evaluate the effectiveness of smoking cessation interventions. The China CDC Institutional Review Board approved the study. The findings showed that the patient self-reported 7-day point prevalence of abstinence rates (PPARs) at 1-month and 3-month follow-ups were 26.2% and 23.5%, respectively. It indicates that interventions provided by SCCs in this study were effective. Comprehensive tobacco control measures should be implemented to increase the willingness of smokers to seek support for quitting in SCCs.
The data collected from patients who visited the clinics for the first time and received follow-up care at 1 month and 3 months after the initial visit encompassed demographic characteristics, smoking status, and other factors. Eligibility criteria for patient participation included: 1) a current smoker at the time of the first clinic visit, and 2) at least 18 years old. Interventions for smoking cessation, provided by trained practitioners in the SCCs, consisted of counseling, counseling combined with first-line medications [including varenicline, bupropion, and nicotine replacement therapy (NRT)] (5), or counseling combined with traditional Chinese medicine (TCM, including acupuncture, ear acupuncture, and Chinese herbal). Generally, physicians recommended medication options to all smokers, particularly those with severe nicotine dependence (except for pregnant women), however, the final decision regarding the use of cessation medications was left to the patients.
Counseling services were delivered in adherence to the established clinical practice guidelines of smoking cessation (3,5), incorporating the use of the 5A’s model (Ask, Advise, Assess, Assist, and Arrange follow-up) in clinical interviews, and encouraging behavior modifications for cessation utilizing the 5R’s model (Relevance, Risks, Rewards, Roadblocks, and Repetition) techniques. The recommended duration for each counseling session was ≥10 minutes (6).
Smoking status was assessed through self-report measures. At the 1-month and 3-month follow-up assessments, patients were asked to report their smoking status by answering the question, “Have you smoked within the past 7 days?” Those who responded “no” were categorized as abstinent. Individuals lost to follow-up were presumed to be smokers. Inactive occupational status included patients who were students, retired, unemployed, and so on. The Fagerstrom Test for Nicotine Dependence (FTND) was utilized to measure nicotine dependence. Data were cleaned using Python (version 3.7.11, Python Software Foundation, Fredericksburg, VA, US) and analyzed with SPSS (version 22, IBM Corporation, Armonk, US). The chi-squared test was employed to examine differences in categorical variables, and a logistic regression model was applied to investigate factors associated with abstinence at the 3-month follow-up. A P-value of less than 0.05 was deemed statistically significant in the analyses.
Between 2019 and 2021, a total of 59,239 patients visited 448 SCCs located across 29 provincial-level administrative divisions (PLADs). The average number of clinical visits at each SCC was 45, 71, and 73 for each of the 3 years, respectively. Follow-up rates at 1-month and 3-month intervals were 69.1% and 50.6%, respectively. The sociodemographic characteristics of the patients are presented in Table 1. The average age of patients was 50.5±14.9 years. Among the participants, 96.5% were male, 28.6% held a college degree, and 68.5% were not currently employed. Furthermore, 46.0% of the patients reported a monthly family income of 5,000 Chinese Yuan (CNY) or higher as shown in Table 1.
Characteristic Sample PPAR at 1-month PPAR at 3-month n (%) % χ2 P value % χ2 P value Overall abstinent rate 59,239 (100) 26.2 23.5 Demographic characteristics Age group (years) <40 15,639 (26.4) 25.6 56.144 <0.001* 22.9 28.631 <0.001* 40–59 26,233 (44.3) 25.2 23.0 ≥60 17,357 (29.3) 28.3 25.0 Gender Male 57,155 (96.5) 26.2 4.102 0.043* 23.4 10.022 0.002* Female 2,073 (3.5) 28.2 26.4 Education status Primary school or below 147,898 (25.0) 26.2 39.484 <0.001* 22.5 19.695 <0.001* High school 27,527 (46.4) 25.2 23.5 College degree or above 16,914 (28.6) 27.9 24.6 Occupational status Inactive 40,571 (68.5) 27.1 48.802 <0.001* 24.1 23.572 <0.001* Active 18,658 (31.5) 24.4 22.3 Family income/month (CNY) <5,000 25,882 (43.7) 26.7 120.995 <0.001* 23.1 173.424 <0.001* ≥5,000 27,256 (46.0) 27.1 25.3 Don’t know or won’t say 6,091 (10.3) 20.4 17.5 Smoking status Number of cigarettes smoked/day group ≤10 18,829 (31.8) 31.0 365.596 <0.001* 26.7 183.210 <0.001* 11–20 28,068 (47.4) 24.9 22.8 21–30 6,763 (11.4) 22.2 21.2 ≥31 5,569 (9.4) 21.7 19.5 Duration of smoking group (years) <20 38,734 (65.4) 26.0 3.709 0.054 23.3 3.199 0.075 ≥20 20,495 (34.6) 26.7 24.0 Nicotine dependence group (score) 0–3 (low) 22,293 (37.6) 28.6 150.393 <0.001* 25.5 96.315 <0.001* 4–6 (moderate) 22,954 (38.8) 26.0 23.1 ≥7 (high) 13,982 (23.6) 22.8 21.1 Past-year quit attempts None 34,651 (58.5) 26.4 1.222 0.543 23.5 0.497 0.780 1–5 times 21,712 (36.7) 26.2 23.5 >5 times 2,865 (4.8) 25.5 24.1 Willingness to quit Within 7 days 35,809 (60.5) 32.8 2227.820 <0.001* 28.5 1492.844 <0.001* Within 30 days 9,928 (16.7) 21.3 21.1 30 days later 13,491 (22.8) 12.5 12.2 Intervention Exhaled carbon monoxide test No 37,757 (63.8) 23.7 336.174 <0.001* 20.8 419.059 <0.001* Yes 21,472 (36.2) 30.6 28.3 Intervention methods Counseling 49,537 (83.6) 25.5 80.043 <0.001* 22.9 98.222 <0.001* Combination of TCM and counseling 2,303 (3.9) 30.1 23 Combination of first-line medications and counseling 7,388 (12.5) 29.8 28.1 Year of intervention (Number of SCCs) 2019 (220) 10,013 (16.9) 28.0 177.35 <0.001* 25.8 848.895 <0.001* 2020 (306) 21,836 (36.9) 28.7 29.2 2021 (371) 27,380 (46.2) 23.7 18.2 Abbreviation: SCCs=smoking cessation clinics; TCM=traditional Chinese medicine; PPAR=point prevalence of abstinence rate; CNY=Chinese Yuan.
*P<0.05.Table 1. Baseline characteristics and abstinence rates at 1- and 3-month follow-ups of patients visiting SCCs — China, 2019–2021.
In terms of smoking behaviors, the average number of cigarettes smoked per day was 18.5±11.3, 79.2% of the patients smoked fewer than 20 cigarettes per day, 62.4% had moderate or high nicotine dependence (with FTND scores of 4 or higher). The average duration of smoking was 24.3±13.8 years. 70.2% of SCCs were equipped with exhaled carbon monoxide (ECO) detectors. Only 36.2% of the patients underwent ECO testing, and a mere 12.5% received a combination of first-line smoking cessation medications alongside behavioral counseling (Table 1).
The self-reported 7-day PPARs at 1-month and 3-month follow-up were 26.2% and 23.5%, respectively. PPARs significantly varied by intervention methods (P<0.001). Patients with higher PPARs were identified among those who were: 60 years old or above, female, holding a college degree, not actively working, having a higher family income, exhibiting low nicotine dependence, possessing a stronger willingness to quit, having undergone ECO testing, and receiving intervention with first-line medications (P<0.05) (Table 1).
The logistic regression analysis indicated that factors predicting abstinence at the 3-month follow-up included being 40–59 years old (OR=1.066; 95% CI: 1.014–1.122), being 60 years old or older (OR=1.306; 95% CI: 1.230–1.387), female gender (OR=1.184; 95% CI: 1.069–1.312), having a high school education (OR=1.062; 95% CI: 1.008–1.119), having a college degree or higher (OR=1.083; 95% CI: 1.015–1.155), a monthly family income of at least 5,000 CNY (OR=1.089; 95% CI: 1.042–1.138), a higher ECO test score (OR=1.397; 95% CI: 1.342–1.455), and receiving a combination intervention of first-line medication and counseling (OR=1.119; 95% CI: 1.056–1.187). Patients with an active occupation (OR=0.924; 95% CI: 0.885–0.966), moderate nicotine dependence (OR=0.824; 95% CI: 0.788–0.861), high nicotine dependence (OR=0.732; 95% CI: 0.694–0.772), planning to quit within 30 days (OR=0.652; 95% CI: 0.618–0.688), and planning to quit after 30 days (OR=0.373; 95% CI: 0.352–0.395) were less likely to exhibit abstinence at the 3-month follow-up (Table 2).
Predictors P value OR (95% CI) Age group (years) <40 1 40‒59 0.013* 1.066 (1.014–1.122) ≥60 <0.001* 1.306 (1.230–1.387) Gender Male 1 Female 0.001* 1.184 (1.069–1.312) Education status Primary school or below 1 High school 0.036* 1.062 (1.008–1.119) College degree or above 0.025* 1.083 (1.015–1.155) Occupational status Inactive 1 Active 0.015* 0.924 (0.885–0.966) Family income/month (CNY) <5,000 1 ≥5,000 <0.001* 1.089 (1.042–1.138) Don’t know or won’t say <0.001* 0.733 (0.681–0.789) Nicotine dependence group (score) 0‒3 (low) 1 4–6 (moderate) <0.001* 0.824 (0.788–0.861) ≥7 (high) <0.001* 0.732 (0.694–0.772) Willingness to quit Within 7 days 1 Within 30 days <0.001* 0.652 (0.618–0.688) 30 days later <0.001* 0.373 (0.352–0.395) Exhaled carbon monoxide test No 1 Yes <0.001* 1.397 (1.342–1.455) Intervention methods Counseling 1 Combination of TCM and counseling 0.126 1.083 (0.978–1.201) Combination of first-line medications and counseling <0.001* 1.119 (1.056–1.187) Abbreviation: SCCs=smoking cessation clinics; TCM=traditional Chinese medicine; PPAR=point prevalence of abstinence rate; CNY=Chinese Yuan.
*P<0.05.Table 2. Predictors of abstinence at 3-month follow-up of patients visiting SCCs — China, 2019–2021.
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