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Since its emergence in late 2019, coronavirus disease 2019 (COVID-19) has been a global threat for over three years (1). After experiencing a large-scale epidemic in February 2020, China entered a normalization stage of prevention and control that began in May 2020 (1–2). During this normalization stage, comprehensive measures were taken to reduce the impact of COVID-19 on health, the economy, and society (2). With the high coverage of COVID-19 vaccines in China, accumulated experience in prevention and treatment, and the presence of the highly infectious but less virulent Omicron variants BA.5.2 and BF.7, “Ten New Measures” were implemented on December 7, 2022 to further optimize prevention and control measures of COVID-19. A recent modeling study estimated the transmission dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BF.7 in Beijing (3). However, no study has evaluated national and regional trends of SARS-CoV-2 infection among the general community-based population in late 2022 and early 2023 during the widespread transmission of Omicron variants BA.5.2 and BF.7 throughout China. To fill this knowledge gap, we evaluated national and regional trends of SARS-CoV-2 infection among the general population using a community sentinel surveillance system during December 2022 and January 2023 to provide SARS-CoV-2 infection data during this critical period.
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A total of 419,984 people were recruited into the community sentinel surveillance cohort of NSCS. The average daily rate of newly positive SARS-CoV-2 infections decreased from 4.13% in Round 1 (December 16–19, 2022) to 0.69% in Round 8 (January 10–12, 2023), with an estimated daily percentage change of −26.1%.
The daily average newly positive rate of SARS-CoV-2 infection in the eight surveillance rounds was found to be statistically significant (P<0.05, Table 1). The rates were 4.13%, 6.36%, 5.18%, 3.96%, 2.43%, 1.87%, 0.97%, and 0.69%, respectively. The epidemic peak occurred during Round 2 (December 20–22, 2022).
Rounds (testing date range) Number of people investigated (n) Number of newly positive (n) Daily average newly positive rate (%, 95% CI) EDPC
(%, 95% CI)P-value Round 1 (December 16, 2022 to
December 19, 2022)139,351 23,019 4.13 (4.03–4.23) −26.1
(−34.8, −16.5)0.001 Round 2 (December 20, 2022 to
December 22, 2022)319,488 60,996 6.36 (6.28–6.44) Round 3 (December 23, 2022 to
December 26, 2022)405,364 83,912 5.18 (5.11–5.25) Round 4 (December 27, 2022 to
December 29, 2022)385,563 45,786 3.96 (3.90–4.02) Round 5 (December 30, 2022 to
January 2, 2023)403,471 39,272 2.43 (2.38–2.48) Round 6 (January 3, 2023 to
January 5, 2023)387,787 21,722 1.87 (1.83–1.91) Round 7 (January 6, 2023 to
January 9, 2023)419,984 16,259 0.97 (0.94–1.00) Round 8 (January 10, 2023 to
January 12, 2023)418,836 8,686 0.69 (0.66–0.72) Note: EDPC represents estimated daily percentage change from Round 1 to Round 8.
Abbreviation: SARS-CoV-2=severe acute respiratory syndrome coronavirus 2; CI=confidence interval; EDPC=estimated daily percentage change.Table 1. Trends of SARS-CoV-2 infection among the general population in sentinel community-based surveillance, China, December 2022–January 2023.
In urban areas, the daily average of newly positive SARS-CoV-2 infections decreased from 4.65% in Round 1 to 0.73% in Round 8, with an EDPC of −27.4% (P<0.05, Table 2). In rural areas, the daily average of newly positive cases decreased from 2.83% in Round 1 to 0.57% in Round 8, with an EDPC of −22.4% (P<0.05). Both the urban and rural positive rates peaked at Round 2, and the disparity between the two rates decreased as they both declined to less than 1% by Round 8 (Table 2 and Figure 1).
Rounds Number of people investigated (n) Number of newly positive (n) Daily average newly positive rate (%, 95% CI) EDPC
(%, 95% CI)P-value Urban areas Round 1 99,239 18,471 4.65 (4.52–4.78) −27.4
(−34.9, −18.9)<0.001 Round 2 239,464 49,501 6.89 (6.79–6.99) Round 3 291,816 62,345 5.34 (5.26–5.42) Round 4 295,095 33,749 3.81 (3.74–3.88) Round 5 314,079 30,490 2.43 (2.37–2.48) Round 6 304,333 15,508 1.70 (1.65–1.74) Round 7 326,732 12,290 0.94 (0.91–0.97) Round 8 327,044 7,126 0.73 (0.70–0.76) Rural areas Round 1 40,112 4,548 2.83 (2.67–3.00) −22.4
(−35.3, −6.9)0.014 Round 2 80,024 11,495 4.79 (4.64–4.94) Round 3 113,548 21,567 4.75 (4.62–4.87) Round 4 90,468 12,037 4.44 (4.30–4.57) Round 5 89,392 8,782 2.46 (2.35–2.56) Round 6 83,454 6,214 2.48 (2.38–2.59) Round 7 93,252 3,969 1.06 (1.00–1.13) Round 8 91,792 1,560 0.57 (0.52–0.62) Note: EDPC represents estimated daily percentage change from Round 1 to Round 8.
Abbreviation: SARS-CoV-2=severe acute respiratory syndrome coronavirus 2; CI=confidence interval; EDPC=estimated daily percentage change.Table 2. Trends of SARS-CoV-2 infection among the general population in sentinel community-based surveillance by location, China, December 2022–January 2023.
Figure 1.Trends of SARS-CoV-2 infection in sentinel community-based surveillance, China, December 2022–January 2023. (A) Stratified by location; (B) Stratified by region.
Note: Investigations in the study were conducted in eight rounds, from December 16, 2022 to January 12, 2023. Round 1 was conducted from December 16–19, 2022; Round 2 from December 20–22, 2022; Round 3 from December 23–26, 2022; Round 4 from December 27–29, 2022; Round 5 from December 30, 2022 to January 2, 2023; Round 6 from January 3–5, 2023; Round 7 from January 6–9, 2023; and Round 8 from January 10–12, 2023.
Eastern region included Beijing, Tianjin, Hebei, Liaoning, Shanghai, Jiangsu, Zhejiang, Fujian, Shandong, Guangdong, and Hainan. Western region included Inner Mongolia, Guangxi, Chongqing, Sichuan, Guizhou, Yunnan, Tibet, Shaanxi, Gansu, Qinghai, Ningxia, Xinjiang, Xinjiang Production and Construction Corps. Central region included Shanxi, Jilin, Heilongjiang, Anhui, Jiangxi, Henan, Hubei, and Hunan.
Abbreviation: SARS-CoV-2=severe acute respiratory syndrome coronavirus 2.
Table 3 shows the epidemic trends of SARS-CoV-2 infection in the three regions. In eastern China, the daily average of newly positive cases of SARS-CoV-2 infection decreased from 4.18% in Round 1 to 0.67% in Round 8, with an EDPC of −28.3% (P<0.05). For central and western China, EDPCs were −28.0% (decreasing from 5.43% to 0.61%, P<0.05) and −21.6% (decreasing from 3.01% to 0.77%, P<0.05), respectively. The daily average of newly positive cases in eastern and western China both peaked during Round 2. As shown in Figure 1, the daily average of newly positive cases converged across regions after Round 6 (January 3–5, 2023), and disparities among regions decreased as all rates declined to 0.6%–0.7% by Round 8.
Rounds Number of people investigated (n) Number newly positive (n) Daily average newly positive rate (%, 95% CI) EDPC (%, 95% CI) P-value Eastern Round 1 39,817 6,654 4.18 (3.98–4.37) −28.3
(−37.4, −17.8)0.001 Round 2 128,620 29,724 7.70 (7.56–7.85) Round 3 192,046 40,904 5.32 (5.22–5.43) Round 4 145,503 16,003 3.67 (3.57–3.76) Round 5 150,416 12,806 2.13 (2.06–2.20) Round 6 153,315 8,496 1.85 (1.78–1.91) Round 7 158,143 5,051 0.80 (0.75–0.84) Round 8 157,516 3,154 0.67 (0.63–0.71) Central Round 1 45,272 9,841 5.43 (5.23–5.64) −28.0
(−38.2, −16.1)0.002 Round 2 81,351 13,425 5.50 (5.34–5.66) Round 3 91,777 24,138 6.58 (6.41–6.74) Round 4 96,699 14,120 4.87 (4.73–5.00) Round 5 101,841 15,402 3.78 (3.66–3.90) Round 6 81,908 5,162 2.10 (2.00–2.20) Round 7 107,850 4,266 0.99 (0.93–1.05) Round 8 106,788 1,958 0.61 (0.56–0.66) Western Round 1 54,262 6,524 3.01 (2.86–3.15) −21.6
(−30.6, −11.4)0.003 Round 2 109,517 17,847 5.43 (5.30–5.57) Round 3 121,541 18,870 3.88 (3.77–3.99) Round 4 143,361 15,663 3.64 (3.54–3.74) Round 5 151,214 11,064 1.83 (1.76–1.90) Round 6 152,564 8,064 1.76 (1.70–1.83) Round 7 153,991 6,942 1.13 (1.07–1.18) Round 8 154,532 3,574 0.77 (0.73–0.81) Note: EDPC represents estimated daily percentage change from Round 1 to Round 8; Eastern region included Beijing, Tianjin, Hebei, Liaoning, Shanghai, Jiangsu, Zhejiang, Fujian, Shandong, Guangdong, and Hainan. Western region included Inner Mongolia, Guangxi, Chongqing, Sichuan, Guizhou, Yunnan, Tibet, Shaanxi, Gansu, Qinghai, Ningxia, Xinjiang, Xinjiang Production and Construction Corps. Central region included Shanxi, Jilin, Heilongjiang, Anhui, Jiangxi, Henan, Hubei, and Hunan.
Abbreviation: SARS-CoV-2=severe acute respiratory syndrome coronavirus 2; CI=confidence interval; EDPC=estimated daily percentage change.Table 3. Trends of SARS-CoV-2 infection among the general population in sentinel community-based surveillance by region, China, December 2022–January 2023.
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