Yixiang Ma; Zixin Fang; Xiaoyan Tao; Shuqing Liu; Qian Liu; Minghui Zhang; Pengcheng Yu; Si Liu; Wuyang Zhu; Yixiang Ma; Zixin Fang; Xiaoyan Tao; Shuqing Liu; Qian Liu; Minghui Zhang; Pengcheng Yu; Si Liu; Wuyang Zhu

doi:10.46234/ccdcw2025.209

[1]

World Health Organization. WHO expert consultation on rabies. 3rd ed. Geneva: World Health Organization; 2018. WHO Technical Report Series, No. 1012. https://iris.who.int/bitstream/handle/10665/272364/9789241210218-eng.pdf?ua=1.

[2]

Liu XQ, Li JY, Zha Y, Wang ZX, Jiang Y, Zhang XY, et al. The efficacy and safety of SYN023 (Zamerovimab and Mazorelvimab injection), the recombinant humanized anti-rabies virus monoclonal antibody mixture, combined with rabies vaccine in a WHO category III rabies post-exposure population: a randomized, double-blind, positive control, phase III clinical trial. Vaccine 2025;61:127289. https://doi.org/10.1016/j.vaccine.2025.127289.

[3]

Ding YH, Wu M, Zhang H, Zhu XX, Hu Y, Li XJ, et al. Safety, pharmacokinetics and pharmacodynamics of SYN023 alone or in combination with a rabies vaccine: an open, parallel, single dose, phase 1 bridging study in healthy Chinese subjects. Antiviral Res 2020;184:104956. https://doi.org/10.1016/j.antiviral.2020.104956.

[4]

de Melo GD, Sonthonnax F, Lepousez G, Jouvion G, Minola A, Zatta F, et al. A combination of two human monoclonal antibodies cures symptomatic rabies. EMBO Mol Med 2020;12(11):e12628. https://doi.org/10.15252/emmm.202012628.

[5]

Tao XY, Tang Q, Rayner S, Guo ZY, Li H, Lang SL, et al. Molecular phylodynamic analysis indicates lineage displacement occurred in Chinese rabies epidemics between 1949 to 2010. PLoS Negl Trop Dis 2013;7(7):e2294. https://doi.org/10.1371/journal.pntd.0002294.

[6]

Reed LJ, Muench H. A simple method of estimating fifty per cent endpoints. Am J Epidemiol 1983;27(3):493 − 7. https://doi.org/10.1093/oxfordjournals.aje.a118408.

[7]

Zeiler FA, Jackson AC. Critical appraisal of the Milwaukee protocol for rabies: this failed approach should be abandoned. Can J Neurol Sci 2016;43(1):44 − 51. https://doi.org/10.1017/cjn.2015.331.

[8]

Baker HJ, Martin DR, Gross AL, Chamorro MF, Naskou MC, Johnson AK, et al. Rabies: who should care? J Am Vet Med Assoc 2022;261(4):592-6. http://dx.doi.org/10.2460/javma.22.09.0420.

[9]

Du Pont V, Plemper RK, Schnell MJ. Status of antiviral therapeutics against rabies virus and related emerging lyssaviruses. Curr Opin Virol 2019;35:1 − 13. https://doi.org/10.1016/j.coviro.2018.12.009.

[10]

Chao TY, Ren SQ, Shen EY, Moore S, Zhang SF, Chen L, et al. SYN023, a novel humanized monoclonal antibody cocktail, for post-exposure prophylaxis of rabies. PLoS Negl Trop Dis 2017;11(12):e0006133. https://doi.org/10.1371/journal.pntd.0006133.