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Perspectives: China Can Substantially Reduce Its High Burden of Stroke and Heart Attack

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    沈阳化工大学材料科学与工程学院 沈阳 110142

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China Can Substantially Reduce Its High Burden of Stroke and Heart Attack

    Corresponding author:

    Dr. Thomas R Frieden, tfrieden@rtsl.org. Thomas R Frieden (MD, MPH) is former director of the US Centers for Disease Control and Prevention, and former commissioner of the New York City Health Department. He is currently President and CEO of Resolve to Save Lives, an initiative of the global health organization Vital Strategies. Resolve works with countries to prevent 100 million deaths and make the world safer from epidemics. Vital Strategies is officially registered as an international non-governmental organization in China, with headquarters in Shandong Province

    Online Date: October 02 2020
    doi: 10.46234/ccdcw2020.211
  • Hypertension, the leading cause of cardiovascular disease, kills 10.7 million people worldwide each year — more than any other cause, and more than all infectious diseases combined (1). Approximately one third of adults globally have elevated blood pressure; of these approximately 1.4 billion people, only 1 in 7 with hypertension are effectively treated so that their blood pressure is reduced to below 140/90 (2).

    China’s hypertension burden mirrors the global situation. A quarter of a billion people in China have hypertension — the most of any country in the world — with 23.5% of the adult population having elevated blood pressure. Only an estimated 10%–15% of those with hypertension are treated effectively such that they have the condition under control (3).

    Each year, 1.8 million people in China die from hypertension, nearly double the number in India despite similar population sizes and rates of hypertension (4). For a productive and healthy future, prevention and control of hypertension is essential. It is also feasible to do so; for example, Canada has improved hypertension control rates to nearly 70% nationwide (5), and Thailand’s rate of blood pressure control increased more than 3-fold, from 8.6% to 30%, between 2004 and 2014 (6), and appears to have continued to increase since.

    The two most effective methods of reducing the strokes, heart attacks, and other health problems hypertension causes are to improve hypertension treatment and reduce the intake of sodium, which is a leading contributor to high blood pressure. Globally over the next 25 years, improving control of hypertension from the current 14% of people with high blood pressure to 50% would prevent about 40 million cardiovascular deaths, and reducing population sodium intake by 30% would prevent another 40 million deaths (7).

    Of all primary care interventions for adults, improvement in control of hypertension can save the most lives, potentially many times the number from many other interventions (8). Excess consumption of dietary sodium increases blood pressure and cardiovascular disease; the average sodium intake in China is approximately double the recommendations of World Health Organization (WHO) and other leading health organizations (9). These two interventions will be integral to achieving Sustainable Development Goal 3.4.1, which aims to reduce the risk of premature death among people aged 30–69 years from noncommunicable diseases by one third by 2030 (10), as well as to achieve the aims of Healthy China 2030 (11).

    Health systems that succeed in hypertension control ensure provision of a technical package with 5 key components: 1) protocols that establish standard treatment; 2) community-based care, including use of health staff at the community level to do more tasks such as blood pressure measurement, medication refills, and medication titration following a protocol, with or without telemedicine or artificial intelligence support; 3) regular and uninterrupted supply of quality medications and blood pressure monitoring equipment; 4) patient-centered services that reduce barriers to adherence including the complete elimination of fees for medical visits and for anti-hypertension medications; and 5) information systems that allow accurate and reliable real-time feedback on blood pressure control to clinical staff and program managers (12). These elements are also reflected in the WHO HEARTS technical package for cardiovascular disease management in primary health care (13).

    From the perspective of hypertension control, four aspects of this technical package are particularly important in the Chinese context:

    1. Adhering to specific, algorithmic treatment protocols to eliminate unwarranted variability in prescribing, and facilitate task-sharing and decentralization, and reduce health system and patient out-of-pocket costs while improving treatment efficacy. Reduced patient costs are demonstrated to increase adherence to treatment regimens and thereby reduce the financial and societal costs of avoidable heart attacks and strokes.

    2. Providing three- or six-month refills with appropriate appointment spacing for stable patients, using virtual consultation and patient self-management when feasible. This will also reduce costs for the health system and for patients and increase patient retention in care. If China is to double, triple, or quadruple the proportion of patients with hypertension who have it under control, it will need to increase the efficiency of treatment — less frequent visits with longer refills are one important way to do this. These reforms, implemented during China's successful campaign to stop COVID-19 by limiting visits to health facilities, are excellent innovations and will benefit patients and the health system if they are made permanent throughout China.

    3. Improving patient access to care by reducing reliance on hospital-centric care and increasing use of community-based primary care. China has committed to shifting its focus and resources toward safe, effective, accessible, and affordable basic health services at lower levels of care (14), and specifically adopting this more integrated approach by augmenting its primary care workforce (15). Making care easier to access will increase treatment adherence, reduce population hypertension rates, and save lives.

    4. Developing a functional health information system with interoperability between health facilities and the ability to collect and analyze data on meaningful, consistent, reliable indicators of blood pressure control. This is essential to program evaluation and improvement.

    Reducing dietary sodium intake and associated hypertension and cardiovascular disease is possible, as has been documented in the United Kingdom (UK) (16) and Finland (17). More recently, the Republic of Korea implemented a multicomponent program that reduced dietary sodium consumption among adults by 24% over a 4-year period, with reductions in population blood pressure and hypertension prevalence (18). Although there are differences in food consumption profiles, lessons from the Republic of Korea program are likely relevant to China and other Asian countries.

    There are 3 primary sources of dietary sodium: 1) sodium added to packaged food during manufacturing; 2) sodium added to food prepared and consumed outside the home (e.g., restaurants, cafeterias, street food vendors); and 3) sodium added in the home, either during cooking or while eating (9). In China, two thirds of dietary sodium intake comes from these in-home sources (19); sodium reduction efforts will need to address this to be successful.

    China already has a model to reduce sodium added in the home: the Shandong-Ministry of Health Action on Salt and Hypertension (SMASH) program. This intensive program used a mix of promotion of potassium-containing, low-sodium salt, community education, mass media, distribution of salt measuring spoons, and collaboration with restaurants and supermarkets to set food standards for sodium content. This intervention led to a reported 25% reduction in sodium intake as measured by 24-hour urine sodium and significant declines in blood pressure (20).

    Urban populations are more likely to consume commercially packaged foods and foods prepared outside the home, and these sources of dietary sodium must also be addressed. Working with packaged food manufacturers to reduce sodium content has been successful in the UK, Republic of Korea, and other countries; mandatory reductions are much more effective than voluntary initiatives, which usually fail. Establishing specific targets to reduce sodium in different food categories nationwide, along with requirements to label sodium content, is a feasible approach.

    In addition, front-of-package labeling highlighting levels of sodium, fats, and sugar help consumers quickly and effectively make healthier choices. In particular, mandatory front-of-package labels that feature warning signs, such as introduced in Chile, have been demonstrated to lead to significant reduction in purchases of sugar-sweetened beverages and are the emerging best practice globally for front-of-pack images (21). Chile’s front-of-package warning labeling of high-salt and high-fat foods is likely to result in both improved options for consumers and improved choices by consumers. Sodium intake can also be reduced in foods prepared and eaten outside the home. For example, strong and mandatory policies which set standards for food that is procured or served on public property have been demonstrated to improve the availability of healthy food in institutions such as school and public workplaces (22).

    Adopting a mix of proven interventions such as those demonstrated in SMASH mandatory policies supporting sodium targets, front-of-package labels, and public food procurement can lead to significant reductions in sodium intake, preventing hypertension and improving its control. However, additional innovative measures should also be investigated for use in China. These include increased use of low-sodium salt and other low-sodium condiments as well as interventions to reduce sodium use in restaurant-prepared foods and to provide customers with information on key nutrients in restaurant menu items.

    Although China has made some progress improving hypertension treatment and reducing dietary sodium intake, stronger action on both fronts can save millions of lives and billions of yuan. China has the opportunity to become a regional and global model for reducing hypertension prevalence and preventing cardiovascular disease, which causes nearly half of all deaths in the country each year (23). Millions of lives could be saved and much disability from stroke, heart attack, blindness, kidney failure, dementia, and other complications of hypertension could be prevented in China if the laudable Healthy China 2030 commitment to hypertension treatment and sodium reduction become realities in practice.

    The fundamental emerging global insight on cardiovascular prevention is clear: the most important issue is economics. High and increasing taxes on tobacco and alcohol, controls on marketing and availability of tobacco and alcohol, much higher, capitated pay for primary care clinicians, a health care payment model that rewards providers substantially for validated hypertension control and eliminates costs for patients, and making healthy, low-sodium food less expensive than unhealthy food are the road not just to health, but also to productivity, economic stability, and societal progress.

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